14453 papers
This prospective cohort study of over 316,000 participants demonstrates that metabolic syndrome significantly increases the risk of developing new-onset depression and anxiety through a dose-response relationship, with central obesity and low HDL cholesterol being key drivers and systemic inflammation partially mediating this association.
This study characterizes a 2026 psittacosis cluster in Zhoushan, China, involving three elderly individuals, by integrating epidemiological tracing with molecular evidence to confirm infected parrots as the primary reservoir and shared indoor environments as the transmission route.
This multimethod study evaluating a hospital's full-scale trauma disaster drill found that while frontline clinical triage was effective, systemic inefficiencies in communication, command coordination, and resource logistics significantly hindered the overall mass casualty response.
The MASTER-EPOC study demonstrates that integrating exacerbation profiles with cardiovascular risk in primary care COPD patients reveals clinically distinct phenotypes, including a "hidden-risk" group of non-exacerbators with cardiovascular disease who face significantly higher hospitalization rates and poorer disease control.
This prospective two-centre cohort study found that while the Muraine endothelium-in hydrodissection technique for DMEK offers faster graft unfolding and equivalent early visual and endothelial outcomes compared to the standard endothelium-out method, it is associated with longer dissection times, higher rates of partial tissue loss, increased 6-month endothelial cell loss, and a significantly greater need for rebubbling due to air-only tamponade.
This study reveals that individuals with chronic ocular pain who also exhibit depressive or PTSD symptoms display distinct regional differences in light-evoked brain responses compared to those without such comorbidities, suggesting that mental health status contributes to heterogeneity in central pain processing and may inform more targeted treatment strategies.
In a retrospective cohort study of 162 ICU polytrauma patients, the Prognostic Nutritional Index (PNI) was identified as the only independent predictor of in-hospital mortality among the evaluated immunological and nutritional scores, outperforming both the CALLY index and HALP score.
This retrospective cohort study of 99 Egyptian patients with EGFR-mutated metastatic non-small cell lung cancer found that while 73.7% received EGFR tyrosine kinase inhibitors, the resulting survival estimates are limited by heavy censoring and missing outcomes among untreated patients, preventing definitive conclusions on treatment effects or population-level access.
This single-arm pilot study demonstrated that laparoscopic implantation of a novel device for splenic nerve stimulation in patients with refractory rheumatoid arthritis was feasible and safe, with preliminary evidence suggesting potential reductions in disease activity and inflammatory biomarkers in some participants.
The STABLE trial, a prospective randomized controlled study, found that sustained breath-hold ventilation during tissue acquisition did not improve diagnostic yield or tool-lesion positioning compared to conventional ventilation in imaging-integrated robotic bronchoscopy for peripheral pulmonary lesions.