4814 papers
This study identifies and validates a five-gene exosome-related prognostic signature for lung adenocarcinoma, demonstrating its strong association with tumor immune microenvironment, drug sensitivity, and clinical outcomes to provide novel biomarkers for prognosis and targeted therapy.
This prospective cohort study demonstrates that in women under 35, diminished ovarian reserve is associated not only with reduced oocyte yield but also with significantly impaired oocyte morphology, lower fertilization and embryo quality rates, and decreased clinical pregnancy outcomes compared to women with normal ovarian reserve.
In a Panamanian cohort of adults with sickle cell disease, lower hemoglobin levels were associated with a reduced risk of avascular necrosis, while higher lactate dehydrogenase levels were linked to an increased risk of acute chest syndrome and avascular necrosis, highlighting the distinct yet overlapping contributions of anemia severity and hemolysis to specific clinical complications.
This case report details two Asian Indian men with markedly divergent outcomes following honeybee sting–induced ischemic stroke, illustrating the condition's complex pathophysiology and variable prognosis while emphasizing the critical need for early neurological assessment and comprehensive management in mass envenomation cases.
This study developed and validated a Logistic Regression model using MIMIC-IV and MIMIC-III data to predict 30-day mortality in intracerebral hemorrhage patients with albumin infusion characteristics, achieving strong predictive performance (AUC > 0.80) and providing interpretable insights via SHAP analysis to guide clinical risk assessment and treatment optimization.
This cross-sectional study at Sunyani Teaching Hospital, Ghana, reveals a 27.6% prevalence of uropathogens among Type 2 diabetic patients, identifies Enterococcus species as the most common isolate, highlights specific risk factors and clinical markers for infection, and confirms that while multidrug resistance is prevalent, meropenem, amikacin, and levofloxacin remain highly effective treatment options.
This pilot case series demonstrates that awake percutaneous nephrolithotomy under modified local anaesthesia is a safe and effective alternative to general anaesthesia for treating renal stones, offering high stone-free rates, stable haemodynamics, and short operative times in settings where general anaesthesia access is limited.
This study demonstrates that inhibiting EphB4 in breast cancer promotes immunogenic cell death and alters glucose metabolism via the Src/STAT3/MYC pathway, thereby transforming the tumor microenvironment from "cold" to "hot" and enhancing the efficacy of immunotherapy.
This study elucidates the mechanism by which *Angelicae Pubescentis Radix* (Duhuo) treats rheumatoid arthritis by integrating network pharmacology and experimental validation to demonstrate that its active constituents suppress synovial fibroblast proliferation and induce apoptosis through the inhibition of the PIK3CA/JAK2/PIK3CG signaling pathway.
This qualitative study involving 30 healthcare providers in the Yogyakarta region identifies substantial barriers within Indonesia's referral system for critically ill children, highlighting the urgent need to improve communication, human resources, and organizational services across pre-referral and referral facilities.