📄 Category

medicine

4814 papers

📄 medicine

Transpulmonary pressures to predict the percentage of alveolar collapse and overdistension in acute respiratory distress syndrome

This study demonstrates that end-expiratory and end-inspiratory transpulmonary pressures accurately predict critical thresholds of alveolar collapse and overdistension in ARDS patients, yet EIT-guided PEEP titration yields higher pressures and improved recruitment compared to esophageal pressure-guided strategies, albeit with a trade-off of increased non-dependent overdistension.

Clément Brault, Yoann Zerbib, Romain Vallee, Rosalie Schoux, Alexis Lambour, Benjamin Swinyard, Valentin Dambrine, Julie (…)2026-07-03
📄 medicine

Adonertinib (FHND9041) versus Afatinib as First-line Treatment for Advanced Non-small-cell Lung Cancer with EGFR Sensitive Mutation (FHND9041-Ⅲ-01): A Multi-centre, Open-label, Randomised Phase 3 Trial

In a multi-centre, open-label, randomised phase 3 trial, adonertinib demonstrated significantly superior progression-free survival and a more favorable safety profile compared to afatinib as a first-line treatment for patients with advanced EGFR-mutated non-small-cell lung cancer, particularly those with Ex19del mutations.

Yuankai Shi, Puyuan Xing, Guowu Wu, Hongbo Wu, Xuhong Mi, Renping Wan, Chao Zhang, Yan Wang, Runxiang Yang, Hui Zhao, Ch (…)2026-07-03
📄 medicine

The projected dementia burden attributable to periodontal disease in England: a modelling study

This modelling study projects that the anticipated growth in periodontal disease prevalence in England could result in over 24,000 additional dementia cases and £548 million in annual societal costs by 2040, highlighting it as a highly prevalent but weak modifiable risk factor where population-level interventions may yield significant benefits despite minimal individual risk.

Edward Coote, Nitesh Patel, Rajesh Vijayanarayanan2026-07-03
📄 medicine

Short-Term Outcome and Associations of Mortality in Children Admitted with Severe Malaria in a Tertiary Health Facility, in South East, Nigeria

This retrospective study of 434 children admitted with severe malaria at a tertiary hospital in South-East Nigeria reveals a 12.2% mortality rate, identifying age under five, urban residence, delayed presentation, and severe clinical complications like shock and impaired consciousness as significant independent predictors of death.

Joseph Ezeogu, Chidi Jude Okoro2026-07-03
📄 medicine

Association Between Insulin Resistance and Obstructive Sleep Apnea in Non-Diabetic Obese Children

This study demonstrates that in non-diabetic obese children, insulin resistance (measured by HOMA-IR) is independently associated with the severity of obstructive sleep apnea, suggesting it could serve as a useful adjunct marker for identifying high-risk patients.

Birce Sunman, Didem Alboğa, Meltem Akgül Erdal, Havva İpek Demir, Burcu Şenkalfa, Doğuş Vurallı, Nagehan Emiralioğlu Ord (…)2026-07-03
📄 medicine

Obesity and fibromyalgia predict the development of “difficult-to-manage” psoriatic arthritis phenotype associated with adverse outcome

This prospective cohort study reveals that obesity and fibromyalgia are independent predictors of a "difficult-to-manage" psoriatic arthritis phenotype, which is associated with higher functional impairment, serious adverse events, and hospitalizations compared to non-difficult-to-manage cases.

Antonios Bertsias, Irini Flouri, Evgenia Emmanouilidou, Argyro Repa, Eleni Kalogiannaki, Sofia Pitsigavdaki, Nestor Avgo (…)2026-07-03
📄 medicine

Bony trigeminal nerve entrapment in autosomal dominant osteopetrosis: a rare cause of secondary trigeminal neuralgia

This paper reports a successful case of complete resolution of refractory trigeminal neuralgia in a patient with autosomal dominant osteopetrosis type 1, achieved through a pretemporal extradural transcavernous approach that decompressed the nerve by addressing bony entrapment caused by petrous bone osteosclerosis.

Sarah Hendrickx, Ruben Dammers, Victor Volovici2026-07-03
📄 medicine

Students’ Perspectives on University Health Services in Public and Private Universities in South-East Nigeria: An Internet-Based Comparative Cross-Sectional Study with Policy Implications for Higher Education in Sub-Saharan Africa

This internet-based comparative cross-sectional study of students in South-East Nigeria reveals that while university health services in both public and private institutions only partially meet student needs, private university students report higher dissatisfaction and face distinct demographic differences, highlighting an urgent need for policy-driven improvements in staffing, infrastructure, and accessibility across Sub-Saharan African higher education.

Chidera Obi, Chisom Ochonma, Stanley Eneh, Francisca Onukansi, Ephraim Ezaka, Favour Uzor, Chinaza Constance, Leo Fozeu (…)2026-07-03
📄 medicine

Reconstructing childhood immunisation during conflict: a mixed-methods cohort evaluation in Myanmar

This mixed-methods cohort study in conflict-affected Myanmar demonstrates that a nurse-led, community-based immunisation programme successfully re-established access and achieved full immunisation in 50% of zero-dose children, highlighting the critical role of community engagement and sustained follow-up despite significant logistical and security challenges.

Daniel Fishbein, Hein Thura Aung, Roxy Ong, Aurora Nyein, Jie Jie, Emily Karenni, Kanyar Maw, Kaung Khant, April Poe, Ma (…)2026-07-03
📄 medicine

Disproportionate microvascular burden emerging at younger ages in early- versus late-onset type 2 diabetes: an age-standardized analysis in Northern China

This study of Northern Chinese patients reveals that early-onset type 2 diabetes is characterized by a more aggressive metabolic profile and a disproportionately higher age-standardized burden of microvascular complications, particularly nephropathy and retinopathy, compared to late-onset disease, underscoring the need for earlier, comprehensive risk assessment that includes factors like serum uric acid.

Paizhalaiti Abudureheman, Tong Liu, Yaxin Liu, Ruixuan Liu, Hao Wang, Hua Shu, Qiu Shi, Yuxin Fan, Ming Liu2026-07-03