4814 papers
This study identifies a specific ubiquitination binding site between NEDD4L and ACE2 and demonstrates that blocking this interaction via point mutation alleviates hypoxia-induced pulmonary arterial hypertension, revealing a novel therapeutic target for the disease.
This study identifies that C5a/C5aR1 signaling specifically activates sensory neuron-associated macrophages in the dorsal root ganglia to drive neuropathic pain via IL-1β, while excluding the involvement of C5aR1 in spinal microglia, peripheral injury-site macrophages, or primary nociceptive neurons.
In a propensity-weighted retrospective cohort study of septic shock patients with tachycardia, phenylephrine failed to improve heart rate control compared to norepinephrine and was associated with increased risks of new renal replacement therapy and fewer ventilator-free days, arguing against its routine use even in this specific population.
This study elucidates that hemodynamic disruption in nephrotic syndrome triggers glomerular barrier injury via endothelial glycocalyx degradation, a mechanism validated through integrated in vivo and organ-on-a-chip models and shown to be effectively mitigated by sulodexide therapy.
This study demonstrates that a KMS-SECI-based educational module combined with video-assisted learning and husband support significantly improves knowledge, self-efficacy, and the rate of early breastfeeding initiation within one hour among primigravida mothers compared to conventional care.
This paper presents a complex postpartum trauma case to illustrate the diagnostic challenges of intraoperative pulmonary embolism under general anesthesia and proposes a structured, physiology-driven framework for clinical escalation that prioritizes objective deterioration over isolated risk factors or ambiguous markers.
This case report describes a woman with severe, cyclical recurrent mouth ulcers linked to hormonal fluctuations, which were successfully diagnosed as progesterone-induced and treated with Dexamethasone and Tamoxifen after extensive inconclusive testing.
This first-in-human study demonstrates that HIV-specific, HIV-resistant CAR T cells can effectively control viral rebound and promote sustained virologic remission in people with HIV, highlighting their potential as a key component of HIV cure strategies.
In a multicenter Korean cohort of heavily pretreated relapsed/refractory diffuse large B-cell lymphoma patients, glofitamab monotherapy demonstrated meaningful efficacy and a manageable safety profile, particularly for those with a longer treatment-free interval, while identifying rapid disease progression as a predictor of limited benefit.
This multicenter study demonstrates that in children undergoing MRI, autonomic regulation (measured by heart rate variability) influences diagnostic confidence and repeat-scan risk through a pathway mediated by psychological distress and behavioral dysregulation, with preparation interventions significantly improving these outcomes.