4814 papers
This systematic review and meta-analysis of ten randomized controlled trials involving 1,231 patients with type 2 diabetes suggests that while a high-protein diet leads to a statistically significant but clinically modest reduction in C-reactive protein levels, further research is needed to confirm its practical significance.
This study demonstrates that a deep learning model trained exclusively on carpal bones from left-hand X-rays, with specific preprocessing techniques, achieves accurate bone age assessment (8.38 ± 0.39 months MAE) on the RSNA dataset, proving that the carpal region alone encodes sufficient information for evaluating children's growth.
This study analyzes 13 years of data from 14 SADC countries using GMM and Random Forest models to identify infant mortality, under-5 mortality, HIV prevalence, and GDP per capita as key determinants of life expectancy, projecting continued regional growth with significant disparities through 2027 while recommending targeted health interventions to address these gaps.
This systematic review synthesizes evidence from 2020 to 2025 to demonstrate that adult asthma arises from the cumulative and interacting effects of behavioral, environmental, socioeconomic, and biological determinants across the life course, rather than from isolated risk factors.
This multilevel cross-sectional study of 502 healthcare workers in Aden, Yemen, reveals a significant gap between favorable attitudes and poor biomedical waste management practices, identifying previous training and facility-level support as critical predictors of safe practices in conflict-affected settings.
This paper describes a six-phase, rule-based payer-side medical audit architecture designed for Colombia's SOAT claims system, which integrates documentary and clinical validation with mandatory human review to address regulatory fragmentation while preserving source-level traceability.
This case report describes a 70-year-old man who developed acute limb ischemia shortly after spinal decompression for presumed neurogenic claudication, revealing that mildly reduced preoperative ankle-brachial indices in high-risk patients should trigger vascular imaging to prevent missed aortoiliac occlusive disease and perioperative thrombotic decompensation.
This analysis of ClinicalTrials.gov reveals that while registered Multiple Sclerosis trials have increasingly adopted patient-centered, cognitive, biomarker, and digital endpoints since 2010, they continue to rarely incorporate explicit measures of progression independent of relapse activity (PIRA) or smoldering disease biology, highlighting a significant gap between modern disease concepts and current trial design.
This study introduces InSilico-K, a drug-agnostic digital twin demonstrating that tumor interstitial fluid pressure acts as a universal barrier specifically to macromolecular biologics based on their high molecular weight, and that telmisartan-mediated decompression of this pressure can dramatically improve therapeutic efficacy for these agents in non-small cell lung cancer without benefiting small-molecule drugs.
A 2024 cross-sectional study at the University of Gondar Comprehensive Specialized Hospital revealed that self-medication is highly prevalent (83.5%) among elderly patients and is significantly associated with female gender, higher monthly income, and lower educational levels, highlighting the urgent need for targeted patient education and stricter regulatory controls on non-prescription drug access.