📄 Category

medicine

5451 papers

📄 medicine

Real- World Use of Complement Inhibitor Therapy in Critically Ill Children With Thrombotic Microangiopathy: Results From the Spanish Multicenter Matucip Registry.

This retrospective study of 40 critically ill Spanish children with thrombotic microangiopathy treated with complement inhibitors reveals that while half had suspected complement-mediated HUS, the other half received off-label therapy for other subtypes, with non-CM-HUS patients experiencing significantly later treatment initiation, more severe extrarenal manifestations, longer PICU stays, and higher rates of discharge hypertension.

Elena González-Río, Lorena Bermúdez-Barrezueta, Sara Bobillo-Pérez, Carmen Espinosa-Pereiro, Antonio Rodríguez-Núñez2026-07-07
📄 medicine

Agreement between bioelectrical impedance analysis and dual-energy X-ray absorptiometry in Parkinson’s disease and controls

While bioelectrical impedance analysis (BIA) demonstrates strong correlation and consistency with dual-energy X-ray absorptiometry (DXA) for assessing body composition in Parkinson's disease, its systematic underestimation of lean mass and wide limits of agreement preclude its use as a direct substitute for DXA in individual clinical settings, though it remains valuable for population-level screening.

Wêndel de Oliveira, Danielle Lima, Walter Junior, João de Luna, Antônio Negreiros, Fábia Lopes, Antonio Junior, Adriano (…)2026-07-07
📄 medicine

Efficacy of Locally Applied Propolis Gel as an Adjunct to Nonsurgical Periodontal Therapy: A Randomized Controlled Clinical Study with Biochemical Evaluation

This randomized controlled trial demonstrates that locally applied propolis gel, when used as an adjunct to nonsurgical periodontal therapy, significantly improves clinical periodontal parameters and reduces prostaglandin E2 levels in patients with stage II grade B periodontitis compared to therapy alone.

Doaa Adel-Khattab, Huda Hashem, Nashwa El-khazragy, Nevine Kheir El Din2026-07-07
📄 medicine

Green Fabrication of Acacia ferruginea Based Silver Nanoparticles Targeting TNF-α and AMPK Receptors for the Management of Haemorrhoids

This study demonstrates that green-synthesized silver nanoparticles derived from *Acacia ferruginea* leaf extract exhibit enhanced antioxidant and anti-hemorrhoidal efficacy in a rat model, supported by physicochemical characterization and computational evidence of interactions with TNF-α and AMPK receptors.

Kusuma C. Churchihal, Mallappa Shalavadi, Bhushan Khombare, Sushma Awati, Bharatesh S. Kittur, Sammed Melavanki, Laxman (…)2026-07-07
📄 medicine

Default Mode Network Connectivity and Nocebo Responses in Migraine: A Functional MRI Study

This prospective fMRI study of migraine patients identifies distinct default mode network connectivity patterns, particularly involving the posterior cingulate cortex and frontoparietal regions, that differentiate individuals prone to nocebo responses from those who are not, suggesting potential neurobiological markers for predicting treatment-related adverse effects.

Ioanna Spanou, Efstratios Karavasilis, Foteini Christidi, Evangelia Kararizou, Georgios Velonakis, Dimos-Dimitrios Mitsi (…)2026-07-07
📄 medicine

Pseudotumoral Schistosomiasis Mimicking Locally Advanced Rectal Carcinoma: A Case Report

This case report describes a rare instance of pseudotumoral rectal schistosomiasis in an Ethiopian man that closely mimicked locally advanced rectal carcinoma clinically and radiologically, underscoring the critical importance of deep biopsy and peripheral eosinophilia in endemic regions to avoid misdiagnosis and unnecessary oncologic treatment.

Yoseph Mulatu Habte, Binyam Mulatu Habte, Philipos Shineda Areda, Hanan Abdulkerim Fethudin, Khalid Arebo Hassen, Abubek (…)2026-07-07
📄 medicine

Micro-costing of hospital care for patients with recessive dystrophic epidermolysis bullosa in the UK

This study utilizes a bottom-up micro-costing approach to demonstrate that the actual hospital care costs for patients with recessive dystrophic epidermolysis bullosa (RDEB) in the UK significantly exceed current funding levels, highlighting the urgent need for accurate resource allocation and cost considerations in the development of new therapies.

Elizabeth I Pillay, Anita Patel, Anna E Martinez, Maria L Bageta, Jemima E Mellerio, Eunice Jeffs2026-07-07
📄 medicine

Protocatechuic aldehyde modulates hepatic cholesterol homeostasis by regulating LDL uptake and bile acid synthesis

This study demonstrates that protocatechuic aldehyde ameliorates high-fat diet-induced hepatic cholesterol dysregulation in rats by upregulating LDLR, LXRα, and CYP7A1 while downregulating PCSK9, thereby enhancing LDL uptake and bile acid synthesis to reduce lipid accumulation and atherosclerotic risk.

Yunying Li, Mingli Yan, Ziqi Liu, Xiaomeng Zhang, Xiaoyu Tan, Shiyao Xu, Yuanhan Li, Qing Lin, Yujing Li, Fangyan He2026-07-07