📄 medicine

From different backgrounds to homogeneity in cardiopulmonary resuscitation knowledge: a pre-post study on instructor-led training to healthcare professionals, medical students and laypeople

This pre-post study demonstrates that instructor-led Basic Life Support training significantly improves CPR knowledge across healthcare professionals, medical students, and laypeople, effectively equalizing theoretical scores regardless of prior background while revealing distinct learning patterns such as cognitive interference for experts and a theoretical-practical gap for laypeople.

Abel Nicolau, Inês Jorge, Inês Lourenço, Gustavo Mendes, Cristina Granja2026-07-05
📄 medicine

Biomechanical Study of a Novel External Fixation Frame Controlling Postoperative Loss of Reduction in Thoracolumbar Fractures: Finite Element Analysis

This finite element analysis demonstrates that a novel Micro-Adjustable External Fixation (MAEF) device provides superior biomechanical stability and stress distribution compared to traditional percutaneous short-segment intermediate screw fixation (PSISF), potentially reducing postoperative complications and accelerating fracture healing in thoracolumbar fractures.

Hui Guo, Jiahao Feng, Yanyan Xue, Kun Wang, Ming Hao, Shaobo Nie2026-07-05
📄 medicine

Dysregulation of the inside-out signaling pathway in CNS-infiltrated pediatric T-cell acute lymphoblastic leukemia

This study identifies the dysregulation of the TCR-mediated inside-out signaling pathway, particularly involving the adaptor protein SKAP1, as a key mechanism driving central nervous system infiltration and relapse in pediatric T-cell acute lymphoblastic leukemia.

Frida Holm, Sabina Enlund, Konstantinos Papadakis, Jacob Short, Katja Pokrovskaja Tamm, Ola Hermanson, Anna Nilsson, Qin (…)2026-07-05
📄 medicine

Diagonal Earlobe Creases Associated with Dental Cone Beam CT Imaged Calcified Cervical Carotid Artery Atheromas: Risk Indicators of Myocardial Infarction

This prospective study of older male dental patients demonstrates that diagonal earlobe creases are significantly associated with calcified cervical carotid artery atheromas detected on cone beam CT, suggesting that the presence of these creases may serve as a clinical risk indicator for future myocardial infarction.

Paulo Couto-Souza, Adriana Leite, Giulia Correia, Claudineia Rocha Machado, Flávia Noemy Kiatake Fontão, Sergio Ignácio (…)2026-07-05
📄 medicine

Thyroid Cancer Following Breast Cancer in CHEK2 Carriers:  Surveillance, Treatment or Genetic Susceptibility?

This paper investigates the multifactorial link between breast and subsequent thyroid cancer, concluding that while increased medical surveillance likely explains most cases, shared genetic susceptibility (such as *CHEK2* mutations) and treatment effects also contribute to the association.

Catherine A Murphy, Aletta Poll, Andrea Eisen, Cezary Cybulski, Steven A Narod2026-07-05
📄 medicine

Latent Profiles of Teaching Self-Efficacy and Clinical Teaching Behaviors Among Clinical Nurse Preceptors and Factors Associated With Profile Membership: A Cross-Sectional Study

This cross-sectional study of 358 clinical nurse preceptors in China utilized latent profile analysis to identify three distinct subgroups based on teaching self-efficacy and clinical teaching behaviors, revealing that older age, established employment, higher professional titles, and more extensive experience and training are significantly associated with membership in higher-performing profiles.

Yiman Hou, Li Zhang, Ming Jin, Yunying Li, Yuan Wang, Tong Cheng, Xiaoya Li, Zhiqiang Wang2026-07-05
📄 medicine

Effect of a Bioactive Mineral-Ionic Mouthrinse on Periodontal Soft Tissue Healing and Postoperative Pain After Tooth Extraction: A Double-Blind Randomized Clinical Trial

This double-blind randomized clinical trial demonstrates that a bioactive mineral-ionic mouthrinse significantly accelerates soft tissue healing and reduces postoperative pain following tooth extraction compared to conventional chlorhexidine and normal saline.

Ammar Almarghlani, Hassan Abed, Shatha Ghonaim, Tala Hotah, Ahmed Ghannam, Badr Othman, Ali alghamdi2026-07-04
📄 medicine

Environmental and occupational exposures are associated with disease progression in interstitial lung diseases: a retrospective cohort analysis

This retrospective cohort study of 765 patients at Duke University found that environmental and occupational exposures are prevalent in interstitial lung disease (ILD) patients and are independently associated with a significantly higher risk of disease progression, including a 10% decline in forced vital capacity, lung transplantation, or death.

Auston D. Stiefer, Ashley Howard, Megan L. Neely, Christine Anderson, Julie Fried, Chad Kloefkorn, Alyssa Soskis, Harvey (…)2026-07-03
📄 medicine

Potential of a Utidelone‑Containing Quadruple Regimen for Taxane‑Pretreated Advanced Nasopharyngeal Carcinoma: A Case Report

This case report demonstrates that a utidelone-containing quadruple regimen (comprising utidelone, carboplatin, nimotuzumab, and zimberelimab) induced a complete response and sustained progression-free survival exceeding 24 months in a taxane-pretreated patient with advanced nasopharyngeal carcinoma and multiple liver metastases, with a manageable safety profile.

Yiran Chen, Yan Ma, Yi Yang, Shu Yan, Xiaojing Jia2026-07-03