📄 Category

medicine

6238 papers

📄 medicine

Endpoint Modernization in Registered Multiple Sclerosis Trials: A ClinicalTrials.gov Analysis of Progression-Sensitive, Biomarker, Patient-Reported, and Digital Outcomes

This analysis of ClinicalTrials.gov reveals that while registered Multiple Sclerosis trials have increasingly adopted patient-centered, cognitive, biomarker, and digital endpoints since 2010, they continue to rarely incorporate explicit measures of progression independent of relapse activity (PIRA) or smoldering disease biology, highlighting a significant gap between modern disease concepts and current trial design.

Viswabhaskar Susarla, Lokesh Katiki2026-07-03
📄 medicine

InSilico-K: a drug-agnostic digital twin showing that molecular weight, not molecular target, governs biologic delivery and its telmisartan-mediated rescue in non-small cell lung cancer

This study introduces InSilico-K, a drug-agnostic digital twin demonstrating that tumor interstitial fluid pressure acts as a universal barrier specifically to macromolecular biologics based on their high molecular weight, and that telmisartan-mediated decompression of this pressure can dramatically improve therapeutic efficacy for these agents in non-small cell lung cancer without benefiting small-molecule drugs.

Junichi Shimada2026-07-03
📄 medicine

Self-Medication Use and Its Associated Factors Among Elderly Patients At University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, 2024

A 2024 cross-sectional study at the University of Gondar Comprehensive Specialized Hospital revealed that self-medication is highly prevalent (83.5%) among elderly patients and is significantly associated with female gender, higher monthly income, and lower educational levels, highlighting the urgent need for targeted patient education and stricter regulatory controls on non-prescription drug access.

Abebech Tewabe, Abedulwas Mohammed Seid2026-07-03
📄 medicine

Perception, performance and usability of a virtual reality scenario for Basic Life Support and automated external defibrillator training: a cross-sectional observational study

This cross-sectional study demonstrates that immersive virtual reality training for Basic Life Support and AED use is a feasible, highly usable, and effective educational tool that significantly enhances performance and knowledge among primary care physicians and nurses.

Marina Sanchez Gomez, Manuel Pardo Rios, Robert Greif, Federico Semeraro, Ana Belen Ocampo Cervantes, Sergio Nieto Cabal (…)2026-07-03
📄 medicine

Knowledge, Perceptions, and Preventive Practices Towards Human Metapneumovirus Among Malaysian Adults: A Cross-Sectional Study

This cross-sectional study of 680 Malaysian adults reveals that while general preventive behaviors are common, specific knowledge about Human Metapneumovirus remains limited, with higher awareness significantly associated with female sex, older age, health-related backgrounds, and prior respiratory infection history, highlighting the need for targeted public health communication to address misconceptions.

Mohd Shahezwan Abd Wahab, Mohd Suhaidi Sha'ari, Muhammad 'Izzuddin Zamery, Nik Aisyah Najwa Nik Mustaffa Shapri, Nur Sya (…)2026-07-03
📄 medicine

Efficacy and Safety of Azacitidine Plus Low-dose Dasatinib Maintenance Therapy for Patients with Intermediate and High-risk Acute Myeloid Leukemia: A Prospective, Randomized, Phase Ⅱ Clinical Trial

This prospective, randomized phase II trial demonstrates that adding low-dose dasatinib to azacitidine maintenance therapy significantly improves overall survival and is well-tolerated in patients with intermediate- and high-risk acute myeloid leukemia.

Jinli Jian, Xiao Tang, Yuancheng Guo, Long Zhao, Shujuan An, Bei Liu2026-07-03
📄 medicine

Fertility preservation strategies and long-term reproductive outcomes in women treated for breast cancer

This cohort study demonstrates that fertility preservation strategies are feasible for young women with breast cancer, with nearly half of those attempting to conceive achieving a live birth, predominantly through spontaneous conception despite exposure to gonadotoxic treatments.

Mathilde Bourdon, Clara Weinstein, Virginie Barraud Lange, Florence Coussy, Lea Melka, Chloe Maignien, Julia Gonnot, Kha (…)2026-07-03