6270 papers
Novel poly-target 2,3-benzodiazepine derivatives, MPTD-01 and BS34-20, significantly improved neurological recovery and survival while attenuating reactive astrogliosis in a rat model of traumatic brain injury, supporting their potential as multi-target neuroprotective agents.
This study identifies sepsis and early fluid overload as independent risk factors for necrotizing enterocolitis in preterm infants and demonstrates that a predictive model combining these clinical factors with elevated serum spermine oxidase (SMOX) and acrolein (ACR) levels offers high accuracy for early NEC detection.
This paper outlines a multidisciplinary approach to skull base tumor management, emphasizing the importance of early diagnosis, osteocutaneous exposure techniques for en bloc resection, and the use of free tissue transfers for reconstruction, based on the authors' experience with 32 patients.
This prospective cohort study demonstrates that colonoscopy exhibits substantial concordance with histopathology and excellent accuracy for malignancy detection, while also validating the clinical utility of routine biopsy in macroscopically normal mucosa, which revealed significant inflammatory pathology in approximately one-fifth of cases.
This study demonstrates that a tertiary medical centre in the Middle East successfully maintained 67% of its baseline surgical activity during the 2026 regional conflict despite a 71% reduction in operating room capacity by implementing a structured 4S (Staff, Stuff, Space, and System) operational framework that balanced service continuity with mass casualty readiness and workforce well-being.
This cohort study identifies extensive talar bone marrow lesions, severe tibiotalar joint effusion, elevated anxiety and depression levels, and impaired walking function as independent predictors of conservative treatment failure requiring surgical intervention in young and middle-aged male patients with first-time acute lateral ankle sprains.
This multinational study validates the 24-item Pharmacology Concept Inventory (PCI) as a reliable, unidimensional, and diagnostically informative tool for assessing conceptual understanding and identifying specific misconceptions across diverse international student cohorts.
In a cross-sectional study of 1,840 routine health examination participants, higher levels of systemic inflammatory biomarkers—specifically the neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI)—were found to be independently and positively associated with elevated intraocular pressure, suggesting a link between systemic inflammation and IOP regulation.
This study demonstrates that having patients perform their own neck encirclement significantly improves the availability of neck circumference data for the NoSAS OSA screening tool in routine practice without compromising diagnostic accuracy.
This paper introduces "Paralogue Annotation," a high-precision computational framework that leverages known pathogenic variants in homologous proteins to accurately predict disease-causing missense variants, offering a complementary and scalable approach for clinical genetic interpretation.