📄 Category

medicine

6374 papers

📄 medicine

Development and temporal validation of an auditable EHR-based risk-ranking pipeline integrating Chinese admission notes and laboratory data for cardiac intensive care: a retrospective cohort study

This retrospective cohort study developed and temporally validated an auditable EHR-based multimodal risk-ranking pipeline for cardiac intensive care that integrates Chinese admission notes with structured data, finding that while the model showed a numerically higher but statistically uncertain improvement in discrimination over structured data alone, its suboptimal calibration and modest incremental gain necessitate further external validation before clinical implementation.

Quan Zuo, Li Zhao, Tao Ge2026-06-28
📄 medicine

Endothelial Activation and Stress Index as a Prognostic Marker and Machine Learning Predictor of Mortality in Mechanically Ventilated ICU Patients: A Multicenter Retrospective Cohort Study

This multicenter retrospective study demonstrates that the Endothelial Activation and Stress Index (EASIX) is an independent predictor of 28- and 90-day mortality in mechanically ventilated ICU patients and serves as a significant feature within an externally validated machine learning framework for risk stratification.

Tianen Zhou, Qiaohua Hu, Juan Feng, Jingtao Xu, Guojun Chen2026-06-28
📄 medicine

Towards Integrated Oncology Care: A Qualitative Study of Providers’ Perspectives on Service Quality within the Chilean National Oncology Network

This qualitative study of Chilean healthcare providers reveals that despite national policies, oncology care remains hindered by structural fragmentation, resource shortages, and a lack of territorial adaptation, necessitating a shift toward more integrated, culturally responsive, and context-sensitive models of care.

Victoria Lermanda, Camilo Oñate, Mariol Luan, Paula Bedregal2026-06-28
📄 medicine

Dynamic LAR trajectories provide interpretable short-term risk stratification for ICU patients with delirium

This retrospective study of 1,982 ICU patients with delirium demonstrates that the lactate-to-albumin ratio (LAR) is an independent predictor of 28-day mortality, with persistently elevated LAR trajectories identifying the highest risk group and outperforming lactate or albumin alone in prognostic accuracy.

Fuhui Yan, Jun Shen, Chang Liu, Shaokang Yang, Meng Xu, Xiliang Fu, Chun Pan2026-06-28
📄 medicine

Temporary Use of Allium™ Ureteral Stent in Long-segment Urethral Strictures: Initial Clinical Experience

This study reports the initial clinical experience of using removable Allium™ ureteral stents as a temporary, minimally invasive alternative for managing long-segment urethral strictures in patients unsuitable for urethroplasty, demonstrating technical feasibility and short-term efficacy while highlighting encrustation as a primary long-term complication that warrants further prospective investigation.

Gokhun Ozmerdiven, Firat Akdeniz, Ayhan Karakose2026-06-28
📄 medicine

Neuromuscular Electrical Stimulation as an Adjunct to Botulinum Neurotoxin Therapy in Facial Movement Disorders: A Prospective Within- Subject Crossover Study

This prospective within-subject crossover study demonstrates that adjunctive neuromuscular electrical stimulation significantly enhances the clinical efficacy and duration of botulinum neurotoxin therapy for facial movement disorders, offering a well-tolerated strategy to improve symptom severity and prolong symptom-free intervals.

Julia Schubert, Albrecht Günther, Florian Rakers, Orlando Guntinas-Lichius, Carsten M Klingner, Stefan Brodoehl, Gerd Fa (…)2026-06-28
📄 medicine

Comparative 3D Gait Analysis: Impact of Total Hip Arthroplasty Stem Anchoring (Metadiaphyseal vs Metaphyseal)

This prospective randomized study utilizing 3D gait analysis and patient-reported outcomes demonstrates that metaphyseal-stem total hip arthroplasty (MTHA) facilitates quicker gait recovery and yields superior functional scores compared to metadiaphyseal-stem implants (MDTHA) at one year postoperatively.

Jan Cerny, Lucie Loukotova, Marek Jelinek, Jan Soukup, Tomas Novotny2026-06-28
📄 medicine

The Hormone-Brain-Emotion Axis in Endocrine Therapy for Early Breast Cancer: Insights from a Survivorship Cohort

This study of women undergoing adjuvant endocrine therapy for early breast cancer reveals that fatigue and emotional distress are the primary, interrelated drivers of perceived cognitive impairment, suggesting that routine screening and management of these modifiable symptoms are essential for improving survivorship care and treatment adherence.

Tiago Pina-Cabral, Vanessa Branco, Patricia Cavaco, Margarida Lagarto, José Pereira, Helena Miranda, Ana Martins2026-06-28
📄 medicine

Prevalence of obstructive sleep apnoea and validation of the OSA-5 questionnaire among children aged 2-7 years with adenotonsillar hypertrophy at Mulago National Referral Hospital, Uganda: a prospective cross-sectional study

This prospective cross-sectional study at Mulago National Referral Hospital found that obstructive sleep apnoea affects 88.5% of children aged 2–7 with adenotonsillar hypertrophy and demonstrated that the OSA-5 questionnaire achieves perfect sensitivity and specificity in diagnosing the condition within this high-risk population, suggesting its utility for prioritizing care in low-resource settings.

Geoffrey Tabu, Justine Namwagala, Rym Hidour, Hellen T. Aanyu, Ivan Kimuli2026-06-28
📄 medicine

Opioid prescribing practices for dyspnea across palliative care settings: a retrospective observational study

This retrospective observational study at a French university hospital reveals that opioid prescribing practices for dyspnea in palliative care are characterized by substantial variability across different settings, with most patients already on opioids prior to specialist involvement and dose adjustments primarily driven by the need for symptom relief.

Amandine Mathé, Anne-Lise Giffard, Véronique Averous, Camille Saussac, Etienne Rivière, Anais Braverman2026-06-28