📄 medicine

Creating Clinically Labeled MIMIC-III PPG Datasets for CAD and CVD Research: A Reproducible Workflow

This paper presents a reproducible workflow for constructing clinically labeled photoplethysmography (PPG) datasets from MIMIC-III, yielding distinct coronary artery disease (CAD) and broader cardiovascular disease (CVD) cohorts with quality-screened waveforms and patient-level clinical annotations to support future cardiovascular research.

Raghunath Reddy, Gautam Kumar, Veeranjaneyulu R2026-06-26
📄 medicine

Predictive Factors of Castration Resistance in Prostate Cancer in Guinean Men : A Retrospective Study of 90 Cases

This retrospective study of 90 Guinean men with advanced prostate cancer identifies a high ISUP score (≥3) as the sole independent predictor of developing castration resistance, underscoring the critical need for early histological diagnosis and prognostic stratification in this population.

MORLAYE FATOUMATA BANGOURA, DEMBA CISSE, ALPHA OUMAR BARRY, YOUSSOUF KEITA, MAMOUDOU BALDE, MAMADOU DIAWO BAH, THIERNO M (…)2026-06-26
📄 medicine

Measuring Quality of Life in Children with Lower-Limb Differences: German Translation and Validation of the GOAL-LD™

This study successfully translated and culturally adapted the Gait Outcomes Assessment List for Children with Lower-Limb Difference (GOAL-LD™) into German, demonstrating its excellent internal consistency and readiness for use in clinical practice and research to assess health-related quality of life in German-speaking children with lower-limb differences.

Bjoern Vogt, Leona Seifert, Georg Gosheger, Robert Roedl, Jan Duedal Rölfing, Anna-Kathrin Hell, Unni G. Narayanan, Greg (…)2026-06-26
📄 medicine

Equity and Efficiency of Healthcare Resource Allocation in Shanghai, China: A Longitudinal Study from 2009 to 2024

This longitudinal study of Shanghai from 2009 to 2024 reveals that while healthcare resource expansion has successfully improved population-based allocation equity, it has simultaneously exacerbated spatial and intra-district inequalities while reducing overall efficiency due to technological regression and urban-suburban structural mismatches, necessitating a strategic shift from scale-driven growth to quality-oriented development.

Xiuzhi Chen2026-06-26
📄 medicine

COVID-19 Pandemic Changes Epidemiology, Clinical Features and Laboratory Markers of Epstein-Barr Virus Infection in Children: A Three-Period Retrospective Study of 438 Cases

This retrospective study of 438 hospitalized Chinese children reveals that the COVID-19 pandemic significantly altered the epidemiology, clinical severity, and laboratory profiles of Epstein-Barr virus infections, shifting the pattern from primary infections during strict containment to increased viral reactivation and severe complications in the post-pandemic period.

Zheng Zhang¹⁺,, Tao Zhan²⁺,, Jiahui Hu2026-06-26
📄 medicine

Beyond Ventilation: The Non-linear Impact of Per Capita Spatial Volume on Nosocomial Respiratory Virus Transmission in Hospital Wards — A Real-World Natural Experiment

This real-world natural experiment demonstrates that, even with identical mechanical ventilation systems, a 52% reduction in per capita spatial volume in hospital wards is associated with a six-fold increase in nosocomial SARS-CoV-2 transmission, establishing per capita volume as a critical, non-linear determinant of infection risk that warrants equal consideration with air exchange rates in hospital design standards.

Ji-Young Rhee, Si Hyeon Han, Young Kyoung Lee2026-06-26
📄 medicine

AI Benefits and Machine Learning Errors - Neurology, Psychiatry and Neurosurgery

This systematic review of 79 studies (2018–2026) highlights that while AI significantly enhances neurology, psychiatry, and neurosurgery through improved diagnostics and surgical precision, it also introduces substantial risks of misdiagnosis and bias—particularly in underrepresented populations and edge cases—necessitating strict error tracking, fairness audits, and human oversight to ensure safe clinical implementation.

Saif M. Hassan2026-06-26
📄 medicine

Phytochemical-Based Protection Against Benzene-Triggered Leukemic Injury Through Hematologic Recovery, Tissue Preservation, and Nrf2/Caspase-3 Modulation in Rats

This study demonstrates that treatment with *Withania somnifera*, either alone or in combination with green tea extract and curcumin, effectively mitigates benzene-induced leukemic injury in rats by restoring hematological parameters, preserving tissue architecture, and modulating Nrf2 and Caspase-3 expression, with the combination therapy showing superior efficacy in addressing oxidative stress and apoptosis.

Nedim çakır2026-06-26
📄 medicine

Post-Landing Orthostatic Intolerance after Spaceflight: Characterization of Intravenous Fluid Resuscitation in NASA Astronauts

A retrospective review of 79 NASA astronauts reveals that post-landing orthostatic intolerance is frequently treated with highly variable, non-standardized intravenous fluid volumes lacking evidence-based guidelines, highlighting an urgent need for physiology-informed protocols for future deep-space missions.

Lydia Johnson Kolaparambil Varghese, Josef Pleticha2026-06-26