Sparse-Observation Multi-Horizon Glaucoma Progression Forecasting with Biologically Constrained Temporal Consistency: A Glaucoma Case Study
This paper introduces a biologically constrained, sparse-observation framework utilizing a novel Temporally Consistent Multi-Horizon (TCMH) loss to accurately forecast multi-year glaucoma progression from just two clinical visits, achieving superior calibration and specificity compared to both baseline models and independent specialist graders.