Longitudinal associations between depressive and anxiety symptom trajectories during pregnancy: comorbidity patterns and the sequential role of second-trimester anxiety
This study of 275 Chinese pregnant women reveals U-shaped trajectories for depressive and anxiety symptoms across trimesters, establishes first-trimester screening cut-offs, identifies lower education as a risk factor for comorbidity, and highlights second-trimester anxiety as a key sequential mediator linking early and late-pregnancy depression.