🦠 Category

microbiology

560 papers

Microbiology explores the invisible world of tiny life forms that shape our health, environment, and even the air we breathe. From bacteria and viruses to fungi and parasites, this field investigates how these microscopic organisms interact with us and each other, driving everything from disease outbreaks to beneficial fermentation processes. Understanding them is crucial for developing new medicines, improving food safety, and combating global health challenges.

At Gist.Science, we make the latest discoveries in this dynamic field accessible to everyone. We process every new preprint uploaded to bioRxiv in this category, transforming dense academic findings into both clear, plain-language explanations and detailed technical summaries. This ensures that whether you are a student, a researcher, or simply curious, you can grasp the significance of cutting-edge science without getting lost in jargon.

Below are the most recent papers in microbiology, curated and summarized directly from the bioRxiv server to keep you at the forefront of discovery.

🦠 microbiology

GM-CSF and M-CSF Driven Differentiation Differentially Regulates Chikungunya Virus Infection and Antiviral Responses in Human Monocyte-Derived Macrophages

This study demonstrates that GM-CSF-differentiated macrophages are highly permissive to Chikungunya virus infection and support robust viral replication, whereas M-CSF-differentiated macrophages resist infection by mounting a potent antiviral state characterized by elevated IFN-alpha and CXCL10 production driven primarily by dsRNA sensing.

Veloz, J., Zyulina, V., Thannickal, S., Chebishev, E., Bernal-Rubio, D., Villanueva Guzman, M. D. M., Wu, C., Valencia (…)2026-03-12
🦠 microbiology

DropletFactory CORE - a droplet cytometry and sorting platform for fast and accessible screening in biotechnology

This paper presents DropletFactory CORE, an affordable droplet cytometry and sorting platform designed to enable high-throughput, accessible single-cell screening of yeast libraries based on fluorescence signals for biotechnology applications.

Veere, R., Zenner, M. N., Afroz, A., Joemaa, R., Olman, T., Bartkova, S., van der Hoek, S. A., Melkic, A., Zheng, A. J. (…)2026-03-12
🦠 microbiology

Hydraulic modelling reveals untreated sewage, not pharmaceutical waste, drives antimicrobial resistance in a small river running through a big city

By combining field monitoring with hydraulic modelling in Hyderabad's Musi River, this study reveals that untreated municipal sewage, rather than pharmaceutical manufacturing waste, is the primary driver of antimicrobial resistance, underscoring the urgent need for improved wastewater management in resource-limited urban environments.

Sonkar, V., Kashyap, A., Pallares-Vega, R., Sasidharan, S. S., Modi, A., Uluseker, C., Chandrakalabai Jambu, S., Mohapat (…)2026-03-11✓ Author reviewed ⓘ
🦠 microbiology

Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant Enterococcus faecium

This study demonstrates that both genetic deletion and pharmacological inhibition of the peptidoglycan hydrolase SagA impair cell wall remodeling in vancomycin-resistant *Enterococcus faecium*, thereby restoring its susceptibility to vancomycin.

Fam, K. T., Chodisetti, P. K., Wang, Z., Homer, J. A., Smedley, C. J., Kitamura, S., Silva, B., Xiong, Y., Hansel-Harris (…)2026-03-11
🦠 microbiology

Parallelised detection of bacteria viability using an electrode array and the Exeter Multiscope

This paper presents a scalable, parallelized 2x2 electrode array microscope system that rapidly determines bacterial viability by detecting fluorescence changes in response to electrical stimulation, offering a promising solution for accelerating antimicrobial susceptibility testing.

Lee, K. K., Horsell, D., Stratford, J., Karlikowska, M., Khattak, S., de-Souza-Guerreiro-Rodrigues, T., Jiang, J., Shaw (…)2026-03-11
🦠 microbiology

Multi-continental detection of Streptococcus pyogenes M1UK: Impact of ssrA SNP on SpeA expression in ancestral and M1UK isolates

This study demonstrates that while a specific *ssrA* SNP enhances *speA* expression and contributes to the global expansion of the *Streptococcus pyogenes* M1UK lineage, the resulting phenotype is not solely determined by this mutation, as read-through and toxin production can occur in its absence and are likely modulated by a complex regulatory network involving CovRS.

Vieira, A., Li, H. K., Zhi, X., Reeves, L., Huse, K. K., Mok, K. Y., Cowen, O., Jauneikaite, E., Coelho, J., Sriskandan (…)2026-03-10
🦠 microbiology

Chiral Histidine-Modified Gold Nanoclusters Loaded into Cationic Lipid Nanoparticles for Treatment of Biofilm-associated Infections

This study demonstrates that encapsulating chiral histidine-modified gold nanoclusters within cationic lipid nanoparticles creates a stable, highly effective platform that synergistically disrupts *S. aureus* biofilms and reduces bacterial burden in device-associated infections through combined redox stress and matrix destabilization.

Ye, Z., Jin, X., Koekman, A., van Steenbergen, M., Liu, Y., Xing, Z., Seinen, C., Khodaei, A., Mastrobattista, E., Sluij (…)2026-03-10