653 papers
Microbiology explores the invisible world of tiny life forms that shape our health, environment, and even the air we breathe. From bacteria and viruses to fungi and parasites, this field investigates how these microscopic organisms interact with us and each other, driving everything from disease outbreaks to beneficial fermentation processes. Understanding them is crucial for developing new medicines, improving food safety, and combating global health challenges.
At Gist.Science, we make the latest discoveries in this dynamic field accessible to everyone. We process every new preprint uploaded to bioRxiv in this category, transforming dense academic findings into both clear, plain-language explanations and detailed technical summaries. This ensures that whether you are a student, a researcher, or simply curious, you can grasp the significance of cutting-edge science without getting lost in jargon.
Below are the most recent papers in microbiology, curated and summarized directly from the bioRxiv server to keep you at the forefront of discovery.
This study establishes a validated in vitro infection system using caecal organoids (caecaloids) that successfully supports the sustained growth and morphological development of *Trichuris muris* larvae, demonstrating that the caecaloid epithelium alone is sufficient to recapitulate key aspects of whipworm development observed in vivo.
This study demonstrates that the recently detected *Plasmodium falciparum* K13 C580Y mutation in Ethiopian isolates functionally confers artemisinin tolerance, as validated by CRISPR-Cas9 genome editing and ring-stage survival assays.
TracePheno is a function-first framework that infers interpretable, publication-ready phenotypes for eight essential trace elements from microbiome gene or KO profiles by utilizing curated marker tiers and explicit decision rules to overcome the limitations of taxonomy-based analysis.
This study reveals that primate TRIM5α proteins restrict most tick-borne orthoflaviviruses but fail to inhibit Powassan virus due to a specific NS3 mutation that enables high replication, ultimately demonstrating that TRIM5α-mediated restraint of viral replication serves as a mechanism to avoid triggering strong early innate immune responses.
This pilot study characterizes the respiratory microbiota of blue, fin, and humpback whales in the Gulf of St. Lawrence, demonstrating that blow microbiome diversity serves as a non-invasive biomarker for individual health, with higher diversity correlating with better skin condition and lower pathobiont abundance.
This study investigates a fatal EEHV1B infection in a captive Asian elephant by analyzing viral dynamics, tissue viral loads, and comparative genomics, revealing high viral loads, optimal sample preservation methods, and evidence of recombination between EEHV subspecies that may impact disease pathogenesis and diagnostics.
This study demonstrates that the Galleria mellonella infection model serves as a reliable, scalable, and cost-effective alternative to mouse models for assessing population-level virulence trends in Pseudomonas aeruginosa, showing a strong correlation with mouse bacteremia results, whereas epithelial cell cytotoxicity assays exhibited a weaker correlation.
This study demonstrates that free-living amoebae act as transient, non-replicative hosts for pathogenic and saprophytic *Leptospira* spp., facilitating their environmental persistence and suggesting a potential role for these protozoa in the ecological maintenance and transmission of leptospirosis.
This study identifies the L,D-transpeptidase LdtB as a critical enzyme for *Mycobacterium tuberculosis* acid resistance and intracellular survival by maintaining peptidoglycan integrity, revealing it as a promising target to enhance the efficacy of beta-lactam antibiotics during infection.
This study reveals that the temperate phage VP882 exploits *Vibrio parahaemolyticus* quorum sensing to optimize its transmission by overcoming host defenses through superinfection and superlysogenization, while the host simultaneously attempts to block attachment via polysaccharide shielding at high cell densities.