653 papers
Microbiology explores the invisible world of tiny life forms that shape our health, environment, and even the air we breathe. From bacteria and viruses to fungi and parasites, this field investigates how these microscopic organisms interact with us and each other, driving everything from disease outbreaks to beneficial fermentation processes. Understanding them is crucial for developing new medicines, improving food safety, and combating global health challenges.
At Gist.Science, we make the latest discoveries in this dynamic field accessible to everyone. We process every new preprint uploaded to bioRxiv in this category, transforming dense academic findings into both clear, plain-language explanations and detailed technical summaries. This ensures that whether you are a student, a researcher, or simply curious, you can grasp the significance of cutting-edge science without getting lost in jargon.
Below are the most recent papers in microbiology, curated and summarized directly from the bioRxiv server to keep you at the forefront of discovery.
This study employs an integrative bioinformatics and machine learning pipeline to identify a candidate pathogenicity island in *Fusobacterium nucleatum* and proposes a novel mechanistic hypothesis linking hemolysin-mediated iron acquisition to cancer progression via oxidative stress and Hippo pathway modulation.
This study introduces a dynamics-led computational pipeline that utilizes high-resolution time-series data and unsupervised clustering to quantify transient dynamics and inoculum effects in *Pseudomonas aeruginosa*, revealing a novel ODE model that captures complex antibiotic behaviors and defines new metrics for distinguishing dynamical regimes.
This paper critiques Hariharan et al.'s 2025 study on naturally occurring defective HIV genomes, arguing that their observational data cannot validly assess the therapeutic potential of interfering particles, that their reported reproductive numbers are internally inconsistent with viral dynamics, and that established alternative mechanisms better explain the observed phenomena.
This study demonstrates that GM-CSF-differentiated macrophages are highly permissive to Chikungunya virus infection and support robust viral replication, whereas M-CSF-differentiated macrophages resist infection by mounting a potent antiviral state characterized by elevated IFN-alpha and CXCL10 production driven primarily by dsRNA sensing.
This paper presents DropletFactory CORE, an affordable droplet cytometry and sorting platform designed to enable high-throughput, accessible single-cell screening of yeast libraries based on fluorescence signals for biotechnology applications.
By combining field monitoring with hydraulic modelling in Hyderabad's Musi River, this study reveals that untreated municipal sewage, rather than pharmaceutical manufacturing waste, is the primary driver of antimicrobial resistance, underscoring the urgent need for improved wastewater management in resource-limited urban environments.
This study demonstrates that both genetic deletion and pharmacological inhibition of the peptidoglycan hydrolase SagA impair cell wall remodeling in vancomycin-resistant *Enterococcus faecium*, thereby restoring its susceptibility to vancomycin.
By analyzing over 4,000 global soil datasets, this study reveals that soil *Legionella* diversity and pathogen abundance are strongly shaped by climatic gradients, with warmer and wetter conditions favoring the detection of various pathogenic lineages beyond the commonly monitored *L. pneumophila*.
This paper presents a scalable, parallelized 2x2 electrode array microscope system that rapidly determines bacterial viability by detecting fluorescence changes in response to electrical stimulation, offering a promising solution for accelerating antimicrobial susceptibility testing.
This study introduces a five-species gastric microbial model community to investigate how interactions with other bacteria, such as resource competition and pH modulation, influence *Helicobacter pylori* colonization and pathogenesis, offering a non-invasive platform for future gastric microbiome research.