1891 papers
This study demonstrates that stable, millisecond-scale neural firing sequences, initially observed in the mouse visual cortex, constitute a ubiquitous and weeks-long invariant scaffold of population activity across the entire mouse brain.
This study utilizes fMRI to demonstrate that understanding non-literal speech, such as irony and sarcasm, relies on the dynamic neural integration of affective prosody and semantics within a network involving the inferior frontal gyrus, temporal regions, and theory of mind areas, with behavioral evidence suggesting a dominance of prosodic cues.
By applying geometric analysis and neural network modeling to pituitary cell populations, this study reveals that intrinsic spontaneous activity drives directed coupling and transient bistability, forming a self-sustained oscillatory system essential for coordinating hormone secretion.
This study demonstrates that nonlinear functional brain network features derived from multiscale entropy analysis of resting-state fMRI data successfully predict individual differences in transcendent thinking among adolescents, outperforming conventional linear connectivity measures and showing no association with global intelligence.
By applying a hierarchical generative model (PV-RNN) to multimodal physiological data, this study reveals that interoceptive attention enhances the precision of latent brain-body interaction dynamics, a neural signature that correlates with adaptive body control and inversely with psychiatric vulnerabilities like anxiety and rumination.
This study reveals that female 5XFAD mice exhibit earlier and more severe amyloid-beta plaque formation and distinct microglial phagocytic responses compared to males during early disease stages, suggesting that sex-specific microglial dynamics contribute to the higher prevalence of Alzheimer's disease in women.
By analyzing single-nucleus RNA sequencing data from 226 adults, this study identifies microglial transcriptional programs, particularly IFN{gamma} signaling, as non-cell-autonomous drivers that predict inter-individual variation in neuronal aging pace, with a critical shift toward inflammatory microglial dominance emerging in midlife.
This study demonstrates that individual differences in low-level locomotor speed and spatial coverage co-vary with an exploratory visual style, supporting the existence of a domain-general "exploration" factor that shapes both movement and attention during free navigation in a large-scale virtual city.
This study demonstrates that in juvenile myoclonic epilepsy, reduced general mental ability is linked to increased thermodynamic rigidity and lower noise in resting-state brain network dynamics, suggesting that both intrinsic circuit abnormalities and pharmacological stabilization may constrain the brain's exploration of functional states.
This study demonstrates that prenatal maternal inflammation, particularly during the second trimester, is associated with altered macro- and microstructural integrity of mesolimbic white matter circuits in offspring observed in late midlife, suggesting a potential biological mechanism linking early-life inflammation to later-life affective and motivational disorders.
This study demonstrates that treating the brain with the highly attenuated PVSRIPO virus safely reprograms microglia via a non-cytopathogenic viral RNA replication mechanism, thereby enhancing their ability to clear neurotoxic amyloid-beta debris and treat gliomas without triggering harmful inflammation.
This study demonstrates that while an intravenous oxycodone self-administration regimen in rats successfully models the incubation of cue-induced craving, it does not concurrently produce persistent negative affective states, likely due to lower drug intake compared to non-contingent escalating dose regimens.
While a specific sulcal interruption in the left posterior occipital temporal sulcus robustly predicts reading skills in typical children, this anatomical feature does not distinguish dyslexic readers or predict their response to intervention, highlighting that educational support rather than fixed neuroanatomy drives reading improvement in dyslexia.
This study demonstrates that in preclinical 5XFAD mice, declines in CSF and plasma Aβ42/Aβ40 ratios correlate with the progression of β-sheet-rich Aβ deposition, validating these fluid biomarkers as sex-dependent, translatable indicators of early Alzheimer's disease pathology.
This paper introduces a novel voxel-wise O-information framework that bridges high-order information theory with standard neuroimaging pipelines to capture complex multivariate brain interactions, demonstrating its utility in revealing age-related reductions in redundancy within the default mode network.
This study demonstrates that low-intensity focused ultrasound (LIFU) non-invasively enhances meningeal lymphatic drainage to prevent cognitive decline and reduce Alzheimer's pathology by activating the Piezo1 ion channel in lymphatic endothelial cells, offering a promising and clinically translatable therapeutic strategy.
This study characterizes YX84, a novel neuroactive steroid with a unique structure that acts as a potent GABA_A receptor full agonist and positive allosteric modulator while also inhibiting NMDA receptors, demonstrating favorable behavioral tolerability in animal models despite requiring further pharmacokinetic optimization.
This study establishes a scalable, optimized human neuron-microglia tri-culture platform using deterministically programmed cells that enables the systematic investigation of neuroimmune interactions and the modeling of genetic variants, such as the TREM2 R47H mutation associated with Alzheimer's disease, on developing neuronal network dynamics.
This paper introduces EmoFB, a biologically inspired deep neural network model that integrates intrinsic affective appraisal and external contextual steering to demonstrate how top-down feedback dynamically reshapes visual representations, improves recognition under ambiguity, and enhances alignment with human brain activity across key emotional and visual processing regions.
This study demonstrates that peripherally administered GLP-1R agonists activate the central amygdala (CeA) to induce hypophagia, a process mediated by multiple CeA neuron populations including Prkcd, Glp1r, and Sst-expressing cells, with Glp1r neurons specifically playing a crucial role in suppressing the consumption of energy-dense, palatable diets.