🧠 Category

neuroscience

1825 papers

Neuroscience explores the intricate machinery of the brain and nervous system, seeking to understand how we think, feel, and move. From the microscopic dance of individual neurons to the complex networks that shape our memories and behaviors, this field peels back the layers of our biological selves to reveal the origins of consciousness and disease.

At Gist.Science, we bring these discoveries directly from bioRxiv, the leading preprint server for biological sciences, to a broader audience. We process every new neuroscience preprint as it is uploaded, transforming dense academic manuscripts into clear, plain-language explanations alongside detailed technical summaries. This ensures that both curious readers and specialists can stay current with the latest breakthroughs before they are formally published.

Below are the latest neuroscience papers we have processed from bioRxiv, offering fresh insights into the workings of the mind.

🧠 neuroscience

A self-complementary recombinant adeno-associated virus vector coding for an anchorless prion protein carrying the G127V mutation extends survival in a rodent prion disease model

This study demonstrates that a self-complementary recombinant adeno-associated virus vector delivering a GPI-anchorless prion protein with the protective G127V mutation significantly extends survival in a rodent prion disease model by slowing proteomic perturbations, thereby establishing a promising framework for future human gene therapies.

Zerbes, T., Verkuyl, C., Zhang, C., Grunnesjoe, S., Eid, S., Arshad, H., Zhao, W., Nasser, Z., O'Shea, T., Belotserkovsk (…)2026-03-27
🧠 neuroscience

Deficits in tail-lift and air-righting reflexes in rats after ototoxicity associate with loss of vestibular type I hair cells

This study demonstrates that in female rats, ototoxicity-induced deficits in tail-lift and air-righting reflexes are primarily driven by the loss of vestibular type I hair cells, with specific reflex impairments correlating to damage in distinct vestibular organs (crista/utricle for tail-lift and utricle/saccule for air-righting).

Palou, A., Tagliabue, M., Beraneck, M., Llorens, J.2026-03-26
🧠 neuroscience

The phosphodiesterase-5 inhibitor vardenafil reverses sleep deprivation-induced amnesia in mice

This study demonstrates that the PDE5 inhibitor vardenafil, particularly when combined with optogenetic engram stimulation, can reverse sleep deprivation-induced amnesia in mice by restoring cGMP signaling and enhancing engram cell reactivation within the dorsal dentate gyrus, thereby revealing the molecular and network mechanisms underlying memory deficits caused by sleep loss.

Paraciani, C., Castoldi, C., Popescu, D. M., Meijer, E. L., Van Den Hoed, O. C., Sarma, A., Wilhelm, S., De Vries, N., R (…)2026-03-26
🧠 neuroscience

When the beat drops - The functional anatomy of cardiac-induced sensory attenuation of auditory processing

By combining cardiac phase-locked magnetocephalography with advanced dynamic causal modelling, this study provides the first empirical validation that cardiac-induced auditory attenuation during systole operates primarily through coordinated local inhibitory gain control (precision-weighting) rather than hierarchical attentional modulation, thereby bridging computational theories of interoceptive-exteroceptive integration with specific laminar cortical mechanisms.

Levy, A. D., Zeidman, P., Friston, K.2026-03-26
🧠 neuroscience

Event-Related Warping: A Toolbox for Temporal Alignment and Jitter Correction in Sequential Experimental Paradigms

Event-Related Warping (ERW) is a novel toolbox that improves temporal alignment and jitter correction in sequential experimental paradigms by warping experimental event templates rather than neural signals, thereby preserving inter-channel timing relationships and enabling coherent recovery of sequential neural dynamics that are typically obscured by temporal variability.

Levy, A., Zeidman, P., Friston, K.2026-03-26
🧠 neuroscience

Over-Synchrony: Higher Maternal Neuroticism Associates with Stronger Interpersonal Neural Synchrony with Child During Passive and Free Interactions

This study reveals that higher maternal neuroticism predicts increased interpersonal neural synchrony with children during passive and free interactions, suggesting that heightened synchrony may reflect over-attunement or excessive monitoring in anxious caregivers rather than optimal relational quality.

Carollo, A., Bizzego, A., Shermadhi, D., Dimitriou, D., Gordon, I., Esposito, G., Hoehl, S.2026-03-26
🧠 neuroscience

Expression levels of α5 subunit-containing GABA-A receptors in the prelimbic cortex are associated with visual perceptual learning

This study demonstrates that reduced expression of α5 subunit-containing GABA-A receptors in the prelimbic cortex impairs visual perceptual learning in rats, suggesting that restoring this specific inhibitory signaling pathway could offer therapeutic benefits for neuropsychiatric disorders characterized by perceptual deficits.

Bailey, M. C. D., Preisler, E., Velazquez Sanchez, C., Marti-Prats, L., Stupart, O., Wilod-Versprille, L. J. F., du Hoff (…)2026-03-26
🧠 neuroscience

Spectral and non-spectral EEG measures in the prediction of working memory task performance and psychopathology

This study demonstrates that incorporating non-spectral EEG features across specific working memory paradigms enhances the prediction of working memory capacity and reaction time variability in a validation dataset, whereas models for psychopathology and task accuracy failed to generalize, highlighting the functional heterogeneity of working memory tasks and the necessity of rigorous validation in brain-behavior research.

Peck, F. C., Walsh, C. R., Truong, H., Pochon, J.-B., Enriquez, K., Bearden, C. E., Loo, S., Bilder, R., Lenartowicz, A. (…)2026-03-26