1844 papers
Neuroscience explores the intricate machinery of the brain and nervous system, seeking to understand how we think, feel, and move. From the microscopic dance of individual neurons to the complex networks that shape our memories and behaviors, this field peels back the layers of our biological selves to reveal the origins of consciousness and disease.
At Gist.Science, we bring these discoveries directly from bioRxiv, the leading preprint server for biological sciences, to a broader audience. We process every new neuroscience preprint as it is uploaded, transforming dense academic manuscripts into clear, plain-language explanations alongside detailed technical summaries. This ensures that both curious readers and specialists can stay current with the latest breakthroughs before they are formally published.
Below are the latest neuroscience papers we have processed from bioRxiv, offering fresh insights into the workings of the mind.
This study demonstrates that SETD1A haploinsufficiency, a genetic risk factor for schizophrenia, specifically disrupts beta- and gamma-frequency synchrony between the prefrontal cortex and thalamic nucleus reuniens during spatial working memory maintenance, while leaving prefrontal-hippocampal connectivity intact.
This study presents a detailed computational model of the human cortical microcircuit, constructed using new experimental data and adapted rodent parameters, which reveals that while human and rat cortices share similar connection counts, the human cortex features lower cell density, more complex neuronal branching, and reduced bouton densities.
This study demonstrates that the ventriloquism aftereffect generalizes across a wide range of sound frequencies following exposure to a consistent audiovisual offset, suggesting that the underlying neural adaptation occurs at a frequency-independent, high-level multisensory spatial stage rather than at early, frequency-specific auditory processing levels.
Using large-scale spatial transcriptomics, this study maps the brain-wide architecture of diurnal transcription in mice and reveals that region-specific rhythmic disruption occurs early in Alzheimer's disease pathogenesis, preceding substantial amyloid plaque deposition.
By combining MEG and pupillometry in older adults, this study demonstrates that individual differences in top-down attention arise from heterogeneous neural network configurations shaped by sensory processing and strategic resource allocation, highlighting the necessity of moving beyond group averages to understand attentional control.
This paper presents a perforated microfluidic microtunnel device that enables large-scale, guided formation of unidirectional neuronal networks from human stem cells, significantly enhancing electrophysiological recording quality and facilitating computer-aided design of future neural architectures.
This paper introduces an open-source, isotropic 7.72 {micro}m/voxel post-mortem human brain dataset acquired via Hierarchical Phase-Contrast Tomography at the ESRF, which bridges the resolution gap between MRI and histology to enable detailed 3D visualization and quantitative analysis of complex neuroanatomy.
This study demonstrates that constitutively active subthreshold Ih and Kir currents jointly regulate the passive properties, intrinsic excitability, and EPSP-spike coupling of medial prefrontal cortex Layer 1 VIP interneurons, thereby shaping their ability to filter signals and modulate information flow within the cortical column.
This study demonstrates that a missense mutation in *Kalrn* causes adolescent-onset dendritic regression specifically in supragranular layers of the visual cortex, leading to impaired mismatch negativity and reduced functional connectivity, thereby linking cytoskeletal alterations to psychiatric-relevant sensory integration deficits.
This study identifies a spatially confined rostral hotspot within the medial nucleus accumbens shell, enriched with Stard5-expressing D1-SPNs, as a critical and specific regulator of hedonic feeding that operates independently of metabolic need or aversive responses.