🧠 Category

neuroscience

1795 papers

Neuroscience explores the intricate machinery of the brain and nervous system, seeking to understand how we think, feel, and move. From the microscopic dance of individual neurons to the complex networks that shape our memories and behaviors, this field peels back the layers of our biological selves to reveal the origins of consciousness and disease.

At Gist.Science, we bring these discoveries directly from bioRxiv, the leading preprint server for biological sciences, to a broader audience. We process every new neuroscience preprint as it is uploaded, transforming dense academic manuscripts into clear, plain-language explanations alongside detailed technical summaries. This ensures that both curious readers and specialists can stay current with the latest breakthroughs before they are formally published.

Below are the latest neuroscience papers we have processed from bioRxiv, offering fresh insights into the workings of the mind.

🧠 neuroscience

Virtual reality headset geometry constrains dorsolateral prefrontal cortex targeting with transcranial magnetic stimulation

This study demonstrates that the physical geometry of virtual reality headsets critically limits concurrent transcranial magnetic stimulation targeting of the dorsolateral prefrontal cortex, with the Meta Quest 2 causing excessive coil-to-scalp distance that exceeds compensable intensity ranges, while the more compact Bigscreen Beyond remains feasible for such combined neuromodulation protocols.

Arden, F., Henneken, P., Turi, Z., Vlachos, A.2026-08-21
🧠 neuroscience

Seeing at Will: Shared Neural Representations of Motion Perception and Intention

This fMRI study demonstrates that volitional intention to perceive specific motion directions establishes decodable, prospective sensory representations in dorsal and lateral visual regions that closely resemble patterns evoked by actual motion perception, indicating that internally generated cognitive states can shape sensory processing before perceptual experience occurs.

Si, W., Choe, E., Heller, N. H., Kohler, P. J., Cavanagh, P., Stoermer, V. S., Tse, P.2026-08-21
🧠 neuroscience

Mesoscale medial temporal lobe connectivity patterns relate to tau pathology and memory in older adults

Using 7 Tesla fMRI and multimodal biomarkers in cognitively unimpaired older adults, this study reveals that while aging reduces medial temporal lobe connectivity, early Alzheimer's tau pathology drives distinct mesoscale connectivity patterns that initially support memory function but ultimately predict future decline.

Fischer, L., Vockert, N., Hoepker Fernandes, J., Garcia-Garcia, B., Roemer-Cassiano, S. N., Franzmeier, N., Gellersen, H (…)2026-08-21
🧠 neuroscience

Population-scale subcellular proteomics reveals intracellular remodelling across the Alzheimer's disease-resilience spectrum

By applying comparative subcellular proteomics to the dorsolateral prefrontal cortex of 75 individuals across the Alzheimer's disease-resilience spectrum, researchers uncovered widespread disease-associated protein relocalization events—particularly in endolysosomal and trafficking pathways—that remain invisible to conventional abundance-based analyses, thereby revealing novel pathological mechanisms and protein functions.

Jolly, H. A., Seghers, P., Balcomb, K., Smith, A. J., Pearson, L., Agrawal, I., Geary, B., Bennett, D. A., Wisniewski, T (…)2026-08-21
🧠 neuroscience

Nucleus raphe magnus serotonin neurons bidirectionally control spinal nociceptive transmission in mice

This study demonstrates that nucleus raphe magnus serotonergic neurons bidirectionally modulate spinal pain transmission in mice through activity-dependent recruitment of specific 5-HT receptors, with tonic and low-level activation inducing analgesia via 5-HT2C (and 5-HT2A) receptors, while prolonged stimulation causes hyperalgesia via 5-HT3 receptors.

Zoe, G., Aude, V., Franck, A., Rabia, B.-B., Thibault, D., Emma, P., Anna, B., Heisler, L. K., Maddalena, B., Arne, B. (…)2026-08-20
🧠 neuroscience

Population-specific transcriptional-state remodeling of cortical and hypothalamic neurons in Alzheimer's disease

This study reveals that Alzheimer's disease drives structured, population-specific molecular remodeling of neuronal states across cortical and hypothalamic regions—including changes in excitability and synaptic programs—that are distinct from and only partially reflected by simple shifts in neuronal population representation.

Sejer, S., Pedersen, M., Lundby, J. M. B., De Jong, N., Kim, D. W.2026-08-20