1795 papers
Neuroscience explores the intricate machinery of the brain and nervous system, seeking to understand how we think, feel, and move. From the microscopic dance of individual neurons to the complex networks that shape our memories and behaviors, this field peels back the layers of our biological selves to reveal the origins of consciousness and disease.
At Gist.Science, we bring these discoveries directly from bioRxiv, the leading preprint server for biological sciences, to a broader audience. We process every new neuroscience preprint as it is uploaded, transforming dense academic manuscripts into clear, plain-language explanations alongside detailed technical summaries. This ensures that both curious readers and specialists can stay current with the latest breakthroughs before they are formally published.
Below are the latest neuroscience papers we have processed from bioRxiv, offering fresh insights into the workings of the mind.
This study demonstrates that the ALS-associated TARDBP K181E mutation drives neurodegeneration in human forebrain organoids by altering TDP-43 RNA-binding specificity to cause cryptic exon inclusion, specifically identifying PRDM2 mis-splicing as a pathological event present in ALS motor neurons.
This paper introduces a novel texture backward masking paradigm using deep network-synthesized masks to demonstrate that recurrent processes critical for challenging object recognition are already recruited in the early stages of the human visual system.
This paper presents and evaluates a modular, low-cost neural recording platform built from commercially available components, demonstrating its feasibility for capturing local field potentials and distinguishing spike-like activity despite current limitations in noise performance and sampling rates.
This study demonstrates that acute total and chronic partial sleep loss differentially alter sleep state boundaries and dynamics, with chronic restriction blurring the distinction between REM sleep and wakefulness while acute deprivation stabilizes slow wave sleep, suggesting these state-dependent measures could serve as biomarkers for tracking treatment effects in clinical populations.
This study demonstrates that while sleep-deprived individuals fail to adaptively downregulate emotional arousal during prolonged and ambiguous threats—leading to maladaptive anxiety—those with adequate sleep quickly normalize their responses, a process supported by resting heart rate variability.
This study demonstrates that acetylcholine and noradrenaline modulate perceptual decision making not by altering the weighting of sensory evidence, but by specifically regulating the rate at which top-down prior expectations are updated in response to new evidence during the learning process.
This study establishes an adult-onset Drosophila model of tauopathy that uncouples neurotoxicity from development, revealing that human tau expression drives sexually dimorphic behavioral outcomes and lifespan reduction while identifying specific genetic modifiers that influence tau-induced dysfunction.
This study identifies a genetically defined parabrachial Ntsr1 neuron population projecting to the ventromedial hypothalamus that, when activated, suppresses food intake and promotes anxiety-like behaviors, thereby mediating the inhibition of feeding during threatening situations.
This study identifies reproducible human reward imaging phenotypes (sign-tracking and goal-tracking) that exhibit differential sensitivity to dopamine D2/D3 receptor modulation, providing a neuroimaging basis for stratifying patients and predicting responses to dopaminergic agents.
This study characterizes the post-embryonic neurodevelopment of *C. elegans*, revealing that its brain connectome maintains a weakly connected, hierarchical structure with a conserved core backbone and rich club organization that progressively strengthens through asymmetric synapse addition and centralization of input hubs.