1306 papers
Neuroscience explores the intricate machinery of the brain and nervous system, seeking to understand how we think, feel, and move. From the microscopic dance of individual neurons to the complex networks that shape our memories and behaviors, this field peels back the layers of our biological selves to reveal the origins of consciousness and disease.
At Gist.Science, we bring these discoveries directly from bioRxiv, the leading preprint server for biological sciences, to a broader audience. We process every new neuroscience preprint as it is uploaded, transforming dense academic manuscripts into clear, plain-language explanations alongside detailed technical summaries. This ensures that both curious readers and specialists can stay current with the latest breakthroughs before they are formally published.
Below are the latest neuroscience papers we have processed from bioRxiv, offering fresh insights into the workings of the mind.
This paper presents a framework for integrating patch-clamp electrophysiology with single-cell proteomics in acute brain slices, demonstrating that electrophysiological stability and retrieval quality directly influence proteomic yield and synaptic representation in individual neurons.
This study demonstrates that cerebellar astrocytes function as multi-timescale processors that decompose norepinephrine inputs into distinct fast and slow calcium signals to differentially modulate synaptic pathways for event-triggered learning and behavioral state maintenance, effectively implementing critic-like computations within neural circuits.
This study demonstrates that while Reln haploinsufficiency does not alter opioid reinforcement or relapse-like behaviors, it enhances acute fentanyl-induced locomotion and dorsal striatal activity, indicating that Reelin specifically modulates acute drug-evoked neuronal activation rather than associative learning processes.
This study demonstrates that gentle, positively valenced tactile stimulation robustly activates specific CGRP-expressing neurons in the lateral parabrachial nucleus—a region traditionally linked to aversion—suggesting these circuits encode the salience or affective significance of somatosensory stimuli rather than exclusively nociceptive input.
This paper presents a comprehensive set of methods and protocols for using optogenetics to manipulate neural activity in *Aedes aegypti* mosquitoes, enabling the causal analysis of specific neural circuits underlying distinct stages of host-seeking and biting behavior through specialized behavioral assays and machine vision tracking.
This study utilizes normative structural MRI modeling to reveal that children with ADHD exhibit heterogeneous, region-specific gray matter volume deviations—particularly in the lateral and orbital prefrontal cortex and striatum—that are obscured by conventional group-level analyses, thereby supporting the value of individualized neuroanatomical profiling for personalized assessment and treatment.
Although neuronal overexpression of Nrf2 in 5XFAD Alzheimer's disease model mice failed to prevent neuronal loss, reduce amyloid plaques, or alleviate neuroinflammation, it successfully decreased BACE1 levels and reduced the accumulation of dystrophic neurites around plaques, likely through mechanisms involving lipid metabolism and microtubule stability.
This paper presents a protocol for performing calcium imaging on acute brain slices from *Octopus vulgaris* hatchlings to characterize single-cell responses to neurotransmitters, a method adaptable to other small invertebrate species.
This paper presents a high-throughput automated pipeline combining Suite2p and Python scripts to analyze tens of thousands of synapses via calcium imaging, enabling sensitive detection of synaptic dysfunction and facilitating drug discovery for cognitive disorders.
This imaging epidemiology study of 2,826 individuals reveals that residing in neighborhoods with high socioeconomic disadvantage is significantly associated with adverse brain morphometry, including accelerated brain aging, reduced total brain volume, and amplified vascular-related regional volume loss.