neuroscience papers | Gist.Science

Neuroscience explores the intricate machinery of the brain and nervous system, seeking to understand how we think, feel, and move. From the microscopic dance of individual neurons to the complex networks that shape our memories and behaviors, this field peels back the layers of our biological selves to reveal the origins of consciousness and disease.

At Gist.Science, we bring these discoveries directly from bioRxiv, the leading preprint server for biological sciences, to a broader audience. We process every new neuroscience preprint as it is uploaded, transforming dense academic manuscripts into clear, plain-language explanations alongside detailed technical summaries. This ensures that both curious readers and specialists can stay current with the latest breakthroughs before they are formally published.

Below are the latest neuroscience papers we have processed from bioRxiv, offering fresh insights into the workings of the mind.

🧠 neuroscience

Counterconditioning Alcohol Cues: Neural and Behavioral Modulation of Automatic Tendencies and Pavlovian-to-Instrumental Transfer in Male Alcohol Users

This study demonstrates that counterconditioning alcohol cues paired with retrieval cues selectively reduces approach biases and recalibrates cue-driven instrumental interference in approach-oriented male alcohol users by restoring frontal N2 and centroparietal P3 neural activity, highlighting the importance of individual tendency profiles for targeted associative interventions.

Verma, A. K., Chivukula, U., Garbusow, M., Kumar, N.2026-03-25

🧠 neuroscience

Exploring Stress-Induced Neural Circuit Remodeling through Data-Driven Analysis and Artificial Neural Network Simulation

By integrating in vivo neural recordings with an adaptive neural network simulation, this study reveals that chronic stress induces behavioral rigidity through a pathological gain shift that stabilizes the CeA-DMS pathway at the expense of BLA-mediated flexibility, a mechanism robustly maintained despite significant structural variability in synaptic coupling.

Lin, F.2026-03-25

🧠 neuroscience

EEG Bad-Channel Detection Using Multi-Feature Thresholding and Co-Occurrence of High-Amplitude Transients

This paper introduces a publicly available MATLAB module for EEG bad-channel detection that combines multi-feature thresholding with co-occurrence-based clustering to identify and group artifactual channels through an interpretable, human-in-the-loop review process, serving as a quality-control step prior to ICA.

Malave, A. J., Kaneshiro, B.2026-03-25

🧠 neuroscience

Preclinical validation of AAV9-TECPR2 gene therapy in a novel knock-in model of TECPR2-related disorder

This study validates a novel TECPR2 knock-in mouse model that recapitulates key disease phenotypes and demonstrates that neonatal AAV9-mediated gene therapy effectively restores sensory-motor function and mitigates neuropathology, offering a promising therapeutic strategy for the currently untreatable TECPR2-related disorder.

Lenfers Turnes, B., Casey-Caplan, P., Mejia, L., Berry, T., Zhao, J., Villa, F., Cropper, E., Arab, M., Zhang, B., Surin (…)2026-03-25

🧠 neuroscience

Cross Domain Consistency of Aesthetic Preference-driven Social Behavior

This study demonstrates that aesthetic preferences exhibit robust cross-domain consistency across art, faces, and scenes, suggesting they are driven by a domain-general latent structure mediated by shared neurophysiological pathways rather than stimulus-specific factors.

Pham, T. Q., Chikazoe, J.2026-03-25

🧠 neuroscience

Mucin-binding protein shuttles enable delivery of brain-targeted therapeutics

This paper introduces "GlycoShuttles," a modular platform utilizing mucin-binding proteins to traverse the blood-brain barrier via the cerebrovascular glycocalyx, thereby enabling efficient delivery of diverse therapeutics to the brain and demonstrating efficacy in mouse models of dementia.

Shi, S. M., Tender, G. S., Xiong, J., Buff, J. K., Park, H. I., Mendiola, J. H., Wilson, E. N., Abu-Remaileh, M., Bertoz (…)2026-03-25

🧠 neuroscience

Synaptic Alterations Are Preceding the Axonal Loss in Optic Atrophy of Wolfram Syndrome Mouse Model

This study demonstrates that in a Wolfram syndrome mouse model, progressive synaptic alterations in the retina's inner plexiform layer, driven by early presynaptic failure, occur prior to overt axonal degeneration and represent the earliest detectable cause of vision loss.

Gurram, V., An, W., Bimal, S., Urano, F.2026-03-25

🧠 neuroscience

AUDITORY-MOTOR SURPRISAL REVEALS LEARNING ACROSS MULTIPLE TIMESCALES DURING EXPLORATION AND PRODUCTION

This study demonstrates that auditory-motor learning operates across multiple timescales, where rapid, context-sensitive adjustments to auditory predictions occur implicitly during exploration, while slower, persistent modifications to motor inferences require sustained, goal-directed training.

Zhang, H., Cantisani, G., Shamma, S.2026-03-25

🧠 neuroscience

VESTIBULAR FUNCTION LOSS ASSOCIATES WITH SENSORY EPITHELIUM PATHOLOGY IN VESTIBULAR SCHWANNOMA PATIENTS

This study demonstrates that vestibular function loss in patients with vestibular schwannomas is significantly associated with the degeneration of sensory hair cells (specifically type I) and damage to calyx endings within the vestibular sensory epithelium, suggesting that the tumor's deleterious impact on the epithelium mediates functional decline.

Borrajo, M., Callejo, A., CASTELLANOS, E., Amilibia, E., Llorens, J.2026-03-25

🧠 neuroscience

Synchronization properties in C. elegans: Relating behavioral circuits to structural and functional neuronal connectivity

Using a computational model of the *C. elegans* nervous system, this study reveals that while electrical synapses shape functional communities that segregate locomotion circuits, other behaviors emerge from the synchronized activity of distributed functional communities, demonstrating how structural connectivity underpins the dynamic relationship between neural function and behavior.

Sar, G. K., Patton, A., Towlson, E., Davidsen, J.2026-03-25

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