958 papers
This study demonstrates that streptozotocin-induced hyperglycemia upregulates and promotes the colocalization of Pax6 and Tgf-β1 in the mouse heart, suggesting that this interaction drives fibroblast-to-myofibroblast differentiation and contributes to diabetic cardiac dysfunction.
This study validated six susceptibility loci (UBE2U, CDKN2A, SIRT1, NAV2, ST8SIA2, and TP53) in German uranium miners, demonstrating that radon exposure significantly modifies lung cancer risk through gene-environment interactions, while also identifying a potential arsenic interaction for SOX5.
This study utilizes proteomic analysis to demonstrate that outer membrane vesicles (OMVs) from both toxigenic and nontoxigenic *Bacteroides fragilis* strains induce distinct yet overlapping molecular responses in intestinal cell lines, including cytoskeletal reorganization and immune modulation, suggesting that while both strains contribute to anti-inflammatory effects, the presence of toxins in the toxigenic strain may temporarily delay this response until cellular damage is repaired.
This retrospective study validates the NUM-score as an effective tool for stratifying the risk of clinically relevant nephrourological malformations in children with febrile urinary tract infections, demonstrating its potential to guide selective imaging decisions and reduce unnecessary diagnostic procedures while maintaining high sensitivity for detecting significant pathology.
This systematic review synthesizes empirical evidence from ten studies published between 2016 and 2026 to evaluate the effectiveness of nursing-led telerehabilitation and digital health interventions, specifically the Bern Aphasia App, VirTele, and TERG, on continuity of care and functional outcomes for post-stroke patients.
This study reveals that the distinct gut microbiota of pancreatic cancer patients, characterized by elevated lipid-associated metabolites, impairs MSLN-CAR-T cell efficacy by upregulating cholesterol metabolism and Treg differentiation, an inhibitory effect that can be reversed by targeting the key enzyme ACAT-1.
This study demonstrates that ensemble machine learning models, specifically Balanced Random Forest, can effectively identify clinically meaningful risk factors for tuberculosis among high-risk groups in Kigali, Rwanda, by leveraging rigorously processed electronic medical records while preventing information leakage.
This cross-sectional actigraphy study of 85 school-aged children in Tyumen reveals that circadian light exposure patterns, particularly elevated nocturnal blue light and reduced daily robustness, are more strongly associated with central adiposity (waist-to-height ratio) than physical activity, sleep duration, or wrist temperature rhythms.
This case report details a 36-year-old electrician in Nepal who developed Seasonal Hyperacute Panuveitis (SHAPU) following moth exposure, revealing a complex etiology involving Human Herpesvirus 7 and *Acinetobacter baumannii* detected via molecular diagnostics, which guided successful management and resulted in stable vision after two years.
Following a focal M1 lesion in macaques, motor recovery is driven by a large-scale network reorganization characterized by an anterior-to-posterior rewiring of the fronto-parietal circuit, where weakened canonical PMv–AIP connections are compensated by reinforced non-canonical PMv–pVIP pathways to restore grasping function.