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Puberty as a Predictor of Changes in the Dual Systems Imbalance Gap: The Moderating Role of Autism Spectrum Disorder

Using Adolescent Brain Cognitive Development data, this study finds that entering puberty significantly widens the dual systems imbalance gap (increasing sensation-seeking while decreasing impulse control) for male youth without autism, whereas this pubertal effect is attenuated in males with autism, while no significant effects were observed for female youth.

Thomas Wojciechowski2026-07-27
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An Exploratory Pilot Study of Beta-Lactam Resistance Patterns in Uropathogenic Escherichia coli Strains Isolated from Pregnant Women with Acute Cystitis in Butembo, Democratic Republic of Congo

This exploratory pilot study from Butembo, DRC, reveals that all six uropathogenic *E. coli* isolates from pregnant women with acute cystitis were multidrug-resistant to common β-lactams but remained susceptible to ceftriaxone-sulbactam, highlighting an urgent need for expanded surveillance and antimicrobial stewardship despite the study's small sample size.

Nuru KASEREKA VUTSEME, Myrtha KAVIRA ZAWADI, Francine KAVIRA MUBEKWA, Fabrice KAMBALE KALUKI, Sifa KAHAMBU MBWEGHEKI, Ch (…)2026-07-27
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Prevalence and Determinants of Early Sexual Debut Among Adolescents and Young Adults in Sub-Saharan Africa: Examining the Role of Digital Access and Sociodemographic Factors in a Multi-Country Cross-Sectional Study

This multi-country cross-sectional study in Sub-Saharan Africa reveals that early sexual debut among adolescents and young adults is prevalent at 7.4% and is significantly driven by country-specific factors, younger age, male gender, and low socioeconomic status, while digital access showed no significant independent association after adjustment.

Fabiola Moshi, Ikunda Dionis, Dayani Adam, Edwin Paul Mseke, Said Hamad Vuai, Sachin Shinde, Justine Bukenya, David Guwa (…)2026-07-27
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Clinical Phenotype and Genetic Characteristics of 5 Cases with Rubinstein‑Taybi Syndrome

This retrospective study of five children with Rubinstein-Taybi syndrome characterizes their core clinical phenotypes, including neurodevelopmental delays and broad thumbs, identifies heterozygous CREBBP pathogenic variants (noting a rare case of maternal inheritance), and highlights hemivertebra malformation as a novel feature to advocate for early genetic diagnosis and multidisciplinary management.

Yu Ying¹, Zha Jian², Li Xiaoyan², Wu Huaping², Yu Xiongying²2026-07-27
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Emergence of New Delhi Metallo-β-lactamase-9 (blaNDM-9) gene in Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates in Africa

This study reports the first identification of New Delhi Metallo-β-lactamase-9 (NDM-9) producing carbapenem-resistant *Acinetobacter baumannii* clinical isolates in Africa, highlighting the emergence of high-risk ST2 strains carrying multiple resistance genes and mobile genetic elements that threaten treatment efficacy.

James Wachira, Collins Kigen, Vanessa Natasha, Erick Odoyo, Allan Wataka, Stephen Ondolo, Luis Pow Sang, Lillian Musila2026-07-27
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Integrating Metabolomics with Proteomics to Systematically Unveil the Mechanisms of Recurrent Spontaneous Abortion

This study integrates metabolomics and proteomics data to reveal that dysregulation in complement/coagulation cascades, extracellular matrix interactions, and metabolic pathways converges on uteroplacental hypoperfusion, thereby elucidating the molecular mechanisms underlying recurrent spontaneous abortion.

HuaWen Shi, JingJing Men, JiaHui Li, Juan Liu, YanNi Li, LiPing Zhao2026-07-27