959 papers
A cross-sectional study of contemporary UK Armed Forces personnel reveals that at-risk drinking remains prevalent, particularly among males, single individuals, and those with prior combat deployment, with the majority of risk occurring at lower consumption levels and a notable tendency for heavier drinkers to decline further study participation.
This study demonstrates that plantain peels, often discarded as waste, possess significant nutritional value—including high levels of carbohydrates, fiber, protein, minerals, and vitamins—making them a viable, sustainable resource for food, animal feed, and industrial applications.
This study demonstrates that blood-based DNA-methylation classifiers often achieve near-perfect apparent discrimination in hematologic malignancy cohorts not due to disease detection, but because of unaccounted mismatches between the cellular compartments of the healthy reference and the diseased samples, rendering such uncorrected validations uninterpretable.
An analysis of nearly 140,000 public genomic records reveals that while carbapenemase-producing Enterobacterales data exhibits distinct source-specific patterns, the overwhelming dominance of clinical samples highlights a significant surveillance blind spot in environmental, animal, and food sectors, indicating that repository composition rather than true prevalence drives current visibility.
This paper presents a month-long longitudinal study demonstrating that while both persuasive and instructional robot behaviors sustain older adults' engagement in cognitive activities, a persuasive interaction style is more effective at fostering positive responses and emotional connection, suggesting that a hybrid approach may best support long-term motivation.
This prospective multicentre feasibility study demonstrates that pharmacist-led medicines use reviews are an acceptable and cost-effective strategy for successfully deprescribing opioids in post-surgical patients within primary care, though challenges in patient identification, variable discharge prescribing, and workforce constraints currently limit the approach's scalability.
By developing a kinetic model based on single-molecule imaging, this study reveals that the spliceosome achieves high-fidelity 3' splice site selection through a partial kinetic proofreading mechanism involving DDX42, where commitment occurs after U2AF binding rather than during initial interaction.
This multicenter retrospective study developed and validated a regression-based predictive model using ten clinical and laboratory risk factors to effectively identify women at high risk for postpartum hemorrhage, demonstrating good discrimination and clinical utility for early risk stratification.
This study aims to evaluate the uptake of core outcome sets in systematic reviews conducted by Chinese researchers across four high-burden diseases and to investigate the knowledge and perceptions of these reviewers through surveys and interviews to inform future implementation strategies.
This study demonstrates that prospectively redesigning clinical trial protocols to reduce structural fragility—specifically by capping eligibility criteria and redistributing load concentration—could prevent approximately 27% of trial terminations, saving an estimated $8.61 billion over six years.