959 papers
This case report describes the first documented instance of *Pantoea septica* bacteraemia in an immunocompetent child, emphasizing the necessity of advanced identification methods like MALDI-TOF MS for accurate diagnosis and the critical role of meropenem in successful treatment.
This mixed-methods study in Abuja, Nigeria, reveals that while maternal willingness to vaccinate children against malaria is moderate to high, uptake is significantly hindered by low awareness, safety concerns, and socioeconomic disparities, necessitating culturally tailored communication and trusted community engagement to improve vaccine acceptance.
This study demonstrates that while Molnupiravir and its active metabolite NHC do not cause direct cardiotoxicity at clinically relevant concentrations in human iPSC-derived cardiomyocytes, supraclinical doses induce distinct, opposing sarcomeric structural changes and downregulate specific cardiac genes, suggesting a need for caution in patients with preexisting cardiovascular conditions.
This case report demonstrates that miLOOP-assisted lens fragmentation combined with 360° goniosynechialysis offers a safe and effective strategy for managing hard nuclear cataracts in eyes with prior glaucoma surgery and IOP dysregulation by eliminating ultrasonic energy, preserving corneal endothelium, and stabilizing intraocular pressure without medication.
This randomized controlled trial demonstrates that using a synergistic combination of 10% povidone-iodine and 70% isopropyl alcohol significantly reduces residual skin flora and the risk of contamination associated with higher BMI compared to 10% aqueous povidone-iodine alone in elective laparotomies, although the observed reduction in surgical site infections did not reach statistical significance.
This cross-sectional study of 415 Chinese patients with primary biliary cholangitis reveals that nearly 40% experience pruritus, which significantly impairs quality of life and correlates with psychological distress, with a paradoxically stronger association between pruritus and depression observed in patients with early-stage disease or those who have achieved biochemical response.
This sequential explanatory mixed-methods study in east-central Uganda reveals that while retention in Intensive Adherence Counselling (IAC) declines progressively among virally non-suppressed adolescents and young people, completing the full IAC cascade significantly improves viral suppression, with peer support, counsellor-led services, and proximity to facilities identified as key facilitators of sustained engagement.
This retrospective study of 14 pediatric patients highlights the heterogeneous clinical presentation and variable electrophysiological findings of Hereditary Neuropathy with Liability to Pressure Palsies (HNPP) in childhood, emphasizing the importance of early genetic testing and diagnosis to guide management and prevent complications.
Despite a motivated healthcare workforce, Saudi Arabia's progress toward hepatitis C elimination is hindered by operational inefficiencies such as supply chain instability, diagnostic delays, and weak care linkage, necessitating systemic improvements in logistics, coordination, and community engagement to achieve national goals.
This One Health investigation of a July 2024 Chandipura virus encephalitis outbreak in Rajasthan, India, identified 58 suspected cases with a 22% fatality rate and detected the virus in both human and cattle samples alongside local sandfly vectors, suggesting a potential zoonotic transmission cycle despite the transmission chain not being fully established.