959 papers
This paper introduces and validates the Clustered Logistic Factor with Random Effects (CLF-RE) framework as a computationally scalable multiple imputation method that effectively recovers incomplete, high-dimensional longitudinal binary data in electronic health records, significantly reducing bias in epidemiologic estimates compared to existing approaches.
This case report demonstrates the safety and feasibility of a combined anesthetic strategy utilizing ultrasound-guided nerve blocks with sedation to maintain spontaneous breathing during tracheoplasty for a patient with severe eccentric tracheal stenosis caused by a malignant tumor.
By reanalyzing single-cell RNA sequencing data from RSV-infected airway organoids with viral transcript capture, this study distinguishes direct infection responses from bystander effects to identify specific injury-remodeling programs and prioritize host-response candidates, such as CD73 and the SYK inhibitor Fostamatinib, for future therapeutic screening.
This study demonstrates that individual differences in sensory noise traits and common-cause priors, derived from a novel bidirectional audiovisual rabbit task and Bayesian causal inference modeling, predict both behavioral susceptibility to multisensory illusions and specific neural signatures of multisensory mismatch processing in the occipital cortex.
This study suggests that lower baseline serum 5-hydroxytryptamine (5-HT) levels serve as an independent predictor of favorable therapeutic response to combined antidepressant therapy in patients with functional dyspepsia, potentially explaining the variable efficacy of such treatments.
This multicenter retrospective study of nearly 200,000 pregnancies in Hangzhou reveals a declining trend in placenta previa incidence to 0.99%, identifying advanced maternal age, non-local floating population status, rural residency, and higher gravidity/parity as significant risk factors that are strongly associated with adverse outcomes such as cesarean sections and prolonged hospital stays.
This prospective cohort study of Chinese adults demonstrates that higher longitudinal hemoglobin A1c–systolic blood pressure index (HSI), particularly persistent elevation over time, is independently associated with an increased, dose-dependent risk of incident stroke.
This study demonstrates that in an independent evaluation of possible sarcopenia screening using CHARLS data, adding anthropometric predictors and model complexity did not improve performance, while highlighting that strict participant isolation is essential to avoid overestimation and that default thresholds often mask critically low sensitivity.
A single 20-minute session of 40 Hz transcranial alternating current stimulation over the dorsolateral prefrontal cortex significantly altered resting-state EEG microstate dynamics in patients with disorders of consciousness, demonstrating measurable neural changes despite the absence of immediate behavioral improvement.
This study developed and externally validated a web-based, interpretable clinical decision support system using 14 predictors to stratify cardio-kidney risk in critically ill patients with diabetic kidney disease, demonstrating robust performance across MIMIC-IV and eICU-CRD cohorts.