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Safety Surveillance During the Introduction of Novel Oral Poliovirus Vaccine Type 2 (nOPV2) in the Central African Republic: Findings from Passive AEFI and Active AESI Surveillance

A retrospective study in the Central African Republic evaluating the safety of the novel oral poliovirus vaccine type 2 (nOPV2) through passive and active surveillance systems found a favorable safety profile with a low reporting rate of adverse events, most of which were mild, thereby supporting the vaccine's continued use while highlighting the need for strengthened pharmacovigilance.

Georges Rodrigue Kouatcho, Salfo Ouedraogo, Gaspard Tekpa, Marie Thérèse Line Mboliyou Tondogba, Edinam Agbenu, Mermoz G (…)2026-07-25

📄 other

Frailty-index state life expectancy and measurement-rule robustness among middle-aged and older adults in China: a longitudinal multistate analysis

This longitudinal multistate analysis of Chinese adults demonstrates that frailty-index-defined state life expectancy exhibits stable robust-to-frail ordering and measurement-rule robustness across cohorts, validating pre-frailty as a dynamic transitional state for evaluating healthy aging.

Kun Zhu, Wen Li, Yu Liu, Zeyu Niu, Degui Chang, Yaodong You2026-07-25

📄 other

Ultrasound-guided stellate ganglion block with lidocaine and dexmedetomidine for refractory electrical storm after acute myocardial infarction: a case report

This case report describes a 46-year-old female with refractory electrical storm following acute myocardial infarction who achieved complete arrhythmia suppression and full recovery after a second ultrasound-guided stellate ganglion block using a combination of lidocaine and dexmedetomidine, suggesting this adjuvant approach may offer more durable efficacy than lidocaine alone.

Lu Kang, Lizhu Xiao, Jing Lu, Xiaohua Zou, Jiefu Tang, Wenwen Tang, Zaitian Zhang2026-07-25

📄 other

Emergency laparoscopic paraovarian cystectomy in a patient with super obesity is feasible with meticulous anesthetic and surgical planning case report

This case report demonstrates that emergency laparoscopic paraovarian cystectomy can be safely and successfully performed in a super-obese patient (BMI 55.5 kg/m²) through meticulous multidisciplinary planning, modified positioning, and the use of specialized instruments.

Atef Darwish, DINA Darwish, Hasna Hassan, Amany Omar, Mohamed Selim2026-07-25

📄 other

Anatomical Biomimetic Reconstruction of the External Rotators Combined with Repa ir of the Zona Orbicularis in Unilateral Artificial Femoral Head Replacement: A Re trospective Cohort Study

This retrospective cohort study of 124 elderly patients demonstrates that anatomical biomimetic reconstruction of the external rotators combined with zona orbicularis repair during unilateral hemiarthroplasty yields superior postoperative functional outcomes and hip stability compared to conventional suture techniques, without significantly increasing operative time or complication rates.

Zaichao Ma, Mengxue Guan, Zengqiang Yang, Biao Li, Shengbo Wang, Zheng Zhang2026-07-25

📄 other

Clinical Outcome of Endovascular Therapy vs Open surgery for for acute iliac artery thrombosis: a retrospective cohort study

This retrospective cohort study of 92 patients with acute iliac artery thrombosis suggests that while open surgery offers better one-year limb outcomes than endovascular therapy, it carries higher cardiovascular risks in specific high-risk subgroups, supporting the need for individualized treatment selection.

Qiqi Wang, Wei Huang, Yang Liu, Chunshui He, Haijun Wei2026-07-25

📄 other

Extracellular vesicle signalling shapes microglial responses and preneoplastic growth during glioblastoma initiation

This study demonstrates that extracellular vesicles released by preneoplastic cells during the earliest stages of glioblastoma initiation reprogram microglial function to promote tumor growth, as inhibiting this vesicle-mediated communication restores microglial morphology and reduces tumor mass.

Ezgi Kiyga, Julie Mazzolini, Dirk Sieger2026-07-25

📄 other

Cost-Effectiveness of Combined GnRHa and rhGH Therapy versus Monotherapy in Girls with Central Precocious Puberty Based on a Markov Model Integrating Real-World and Pooled Published Cohort Data

This study utilizes a Markov model integrating real-world and pooled cohort data to demonstrate that while adding recombinant human growth hormone to GnRHa therapy for central precocious puberty may be cost-effective for lighter children with significant height deficits under a Chinese healthcare-payer perspective, the conclusion remains sensitive to body weight, treatment duration, and the substantial quality-of-life burden associated with daily injections.

Wei Song2026-07-25

📄 other

Traffic Regulation Literacy, Risk Perception and Safety Practices among Motorbike Riders in Delta State, Nigeria

This study, grounded in the Theory of Planned Behaviour, investigates motorbike riders in Agbor, Delta State, finding that while their traffic regulation literacy and risk perception are generally moderate to high and positively influence safety practices, actual compliance is frequently undermined by economic pressures, passenger demands, and infrastructural or enforcement limitations, necessitating integrated, context-sensitive interventions to improve road safety.

Benjamin Oke Ujevbe, Henry Ikechukwu Imah, Caroline Ochuko Alordiah2026-07-25

📄 other

Profile and care pathway of men who have sex with men on pre-exposure prophylaxis in Lomé, Togo, in 2025: a cross-sectional study (Key-PrEP Study)

This 2025 cross-sectional study of 2,433 men who have sex with men in Togo reveals a low PrEP follow-up rate of 15.5%, with higher attendance significantly associated with initiating a continuous regimen and starting care in Lomé rather than Aného.

Kokou Herbert Gounon, Oumarou I. Wone Adama, Fifonsi Adjidossi Gbeasor-Komlanvi, Harold Régis Kouanfack, Yao Rodion Konu (…)2026-07-25

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