959 papers
This study reveals that antiviral antibodies in severe COVID-19 acquire broad autoreactivity through a charge-driven mechanism, where affinity maturation enriches positively charged residues in antibody binding regions to target negatively charged viral and self-antigens.
This retrospective study demonstrates that CMV immunoblot band patterns correlate systematically with IgG avidity, identifying absent IgG gB1 reactivity as a specific marker for very recent primary infection and absent IgG avidity gB2 as a highly sensitive indicator for timing maternal CMV infection during pregnancy.
This propensity score-matched study demonstrates that cementless short-stem total hip arthroplasty yields excellent and comparable mid-term clinical outcomes and implant survivorship in patients over and under 60 years of age, despite a higher incidence of intraoperative femoral fractures in the older group.
This retrospective analysis of the National Inpatient Sample from 2016 to 2022 reveals a substantial rise in hospitalizations for acute kidney injury superimposed on chronic kidney disease, highlighting significant racial and sex-based disparities where Black patients face higher risks of CKD comorbidity and dialysis initiation, while female patients demonstrate lower mortality and dialysis rates.
This empirical study examines the experiences of creative practitioners in Iran with Generative AI, revealing how geopolitical constraints and technical limitations shape their adoption through dominant director mental models, compensatory labor, and the emergence of bottom-up "Folk Ethics" to navigate systemic inequities.
This micro-CT study reveals significant regional variations in the trabecular microarchitecture of the odontoid process, demonstrating that the denser structure of Region I contrasts with the more porous and mechanically weaker Regions II and III, thereby providing a structural basis for the Anderson-D'Alonzo fracture classification and fracture susceptibility.
By combining 7-tesla fMRI with psychophysics, this study provides direct evidence that a coordinated subcortico-cortical network, specifically involving the superior colliculus, medial pulvinar, and visual cortex, supports rapid ensemble-based outlier detection in humans by encoding global statistical deviations rather than local physical contrast.
This study demonstrates that the novel fluorescent probe pTP-TFE outperforms the standard AT8 antibody in detecting early, phosphorylation-independent tau oligomers in Progressive Supranuclear Palsy brain tissues, revealing a widespread oligomeric pool that precedes mature aggregates and highlighting its potential for early diagnosis and monitoring disease progression.
This study reveals that patients with non-presyncopal vasovagal syncope are significantly older, predominantly male, have a higher body mass index, experience a shorter disease duration, and suffer from falls more frequently compared to those with presyncopal symptoms.
This prospective cross-sectional study of 70 children with cortical visual impairment in Nepal demonstrates that parental concerns evolve with functional vision phases and age, suggesting that combining caregiver-reported observations with the CVI Range assessment can enhance early identification and support individualized rehabilitation planning despite the lack of statistically significant differences in standard visual acuity metrics across phases.