Haematocrit and Shear Rate Modulate Local Cell-free Layer Thickness and Platelet Margination in Blood Flow Along a Sinusoidal Wall
This study utilizes 3D simulations to demonstrate that hematocrit levels and local shear rates modulate cell-free layer thickness and platelet margination along sinusoidal walls, revealing that low hematocrit promotes platelet accumulation at crests while higher hematocrit leads to uniform distribution, thereby offering mechanistic insights into the coupled evolution of vessel topography and thrombosis.