Controlled kHz laser-driven electron irradiations for pre-clinical applications
This paper reports the first successful in-air irradiation of biological samples using stable, kHz laser-driven electron beams, demonstrating promising pre-clinical results of normal tissue sparing in zebrafish embryos while maintaining anticancer efficacy in glioblastoma cells, thereby marking a significant milestone toward the clinical translation of laser-plasma accelerators.
C. M. Lazzarini, M. Favetta, E. R. Szabo, I. Zymak, L. V. N. Goncalves, M. Jech, S. Lorenz, M. Nevrkla, J. Sisma, A. Spadova, F. Vitha, R. Antipenkov, P. Bakule, A. Grenfell, V. Sobr, W. Szuba, J. Dudas, A. Ebert, R. Molnar, R. Polanek, S. V. Bulanov, K. Hideghety, G. M. GrittaniThu, 12 Ma🔬 physics