1390 papers
This study demonstrates that intravenous administration of human umbilical cord-derived mesenchymal stromal cells (UC-MSCs) attenuates neurogenic degeneration and behavioral abnormalities in an infantile acute encephalopathy mouse model by suppressing neuroinflammation and modulating microglial activation.
This study demonstrates that Fragile X syndrome is characterized by region-specific alpha reactivity deficits and distributed network alterations without global alpha slowing, supporting a multi-system model of dysfunction where these dynamics serve as a promising translational biomarker.
This study reveals that TopBP1 condensates act as central architectural hubs that orchestrate nuclear actin assembly and nuclear envelope integrity via ATR-mTOR signaling to maintain genome stability during replication stress, a mechanism that is hijacked by chemo-resistant colorectal cancer cells to promote survival.
Through computational simulations, this paper argues that the brain's valuation system is evolutionarily designed to generate diverse, non-arbitrary subjective values through stochastic learning and resonance, thereby establishing that subjectivity possesses an underlying objective basis.
This study assesses how past and future land-use changes impact habitat suitability and connectivity for the Iberian wolf, brown bear, and Iberian lynx, revealing that while overall habitat availability has remained stable, agricultural intensification poses a severe future threat by increasing fragmentation and reducing connectivity, whereas rural abandonment offers potential improvements.
This study reveals that spreading α-synuclein accumulates at tri-organelle contact sites to stabilize and rewire organelle communication, thereby impairing neuron-astrocyte mitochondrial quality control by disrupting mitochondrial transfer to astrocytes.
This systematic review of 122 neuroimaging studies highlights the shift toward individualized normative modeling in psychiatry and neurology, identifies critical gaps in empirical foundations and reporting transparency, and introduces the 18-item NORMA checklist to standardize model construction, validation, and clinical application.
This study introduces a risk-aware stochastic framework to model survival–diversity trade-offs in synthetic yeast SCRaMbLE, revealing how event probabilities and rearrangement types (such as inversions and duplications) influence viability selection and structural diversity while identifying optimal parameters for balancing clone survival with genomic variation.
This study integrates transcriptome and co-expression network analyses to identify key gene modules and hub genes, revealing that a brassinosteroid–MAPK–cell cycle regulatory program drives increased husk number in maize.
This paper presents a biologically grounded neurocomputational model demonstrating that Hebbian consolidation during non-REM sleep transforms context-bound episodic sequences into generalized semantic representations, while REM sleep fosters fragmented, creative associations through cortical disengagement and noise.