🧬 Category

q-bio

5759 papers

🧬 biology

Integrated bulk and single-cell transcriptomic analysis identifies BCHE and FOXM1 as oxidative-stress markers linked to prognosis and immune-microenvironment remodeling in nasopharyngeal carcinoma

This study integrates bulk and single-cell transcriptomic analyses of nasopharyngeal carcinoma to identify BCHE and FOXM1 as oxidative-stress markers that predict patient prognosis and reflect immune-microenvironment remodeling, with BCHE serving as a robust independent prognostic factor and FOXM1 marking a high-risk malignant state.

Zhao Chen, Dan Wu, Bo Sun, Changyan Liu, Mingli Zhao, Yi Tian, Xiaodan Kong, Can Zhou2026-11-02
🧬 biology

The Cementerio Norte Osteological Collection: A New Documented Skeletal Series From Argentina

This paper introduces the Cementerio Norte Osteological Collection, a newly established, ethically managed, and fully documented series of 65 skeletal remains from San Andrés de Giles, Argentina, which serves as a vital resource for bioanthropological and forensic research by complementing existing regional samples with chronological continuity.

Leandro Luna, Karina Bustamante, Renata Calissano, Marianela Biase, Gala Maruscak, Martina Molinuevo, Sabina Oliva, Mayr (…)2026-11-02
🧬 biology

Parabolic flight-induced gravity variations initiate acute functional and transcriptional responses in cardiac organoids

This study demonstrates that exposing mouse cardiac organoids to the rapid gravity variations of a parabolic flight triggers immediate, maturation-dependent functional changes and distinct transcriptional responses related to calcium homeostasis, mitochondrial function, and stress pathways, establishing this model as a valuable platform for investigating the early mechanisms of cardiac adaptation to altered gravity.

Emma Yamagata Cretin, Héloïse Réthoré, Frank Yates, Côme Rossary, Patrick Gonzalez, Callum Burnard, David Gosselin2026-11-02
🧬 biology

Has climate change altered Jan Mayen Island Arctic Charr life-history traits and feeding ecology?

Despite rising temperatures on Jan Mayen Island over the last six decades, the landlocked Arctic charr population in Lake Nordlaguna has shifted to a life-history strategy of maturing at younger ages and larger sizes likely due to limited food supply, while maintaining stable trophic niches and exhibiting high genetic distinctiveness from other North Atlantic populations.

Jan G. Davidsen, Aslak D. Sjursen, Samantha Crowley, Stig Skreslet, Margrét Thorsteinsson, Gaute Kjaerstad, Eiliv Larsen (…)2026-11-02
🧬 biology

Blocking beta-adrenergic receptors during stress mitigates gut microbiome dysbiosis

This study demonstrates that pharmacologically blocking beta-adrenergic receptors during chronic social stress in mice prevents stress-induced gut microbiome dysbiosis and partially restores sociability, whereas blocking alpha-1 receptors improves sociability without affecting the microbiome.

Brian Corbett, Chrisann Bryan, Fatmanur Kilic, Isabel Garcia, Muhammad Arfan, Anh Ly, Hay Kwok, Victory Miranda, Ashfi B (…)2026-11-02
🧬 biology

The Linaria amethystea complex: convergence, divergence and radiation in the western Mediterranean

This study utilizes phylogenetic analyses of plastid and nuclear DNA to reveal that the morphological diversity within the *Linaria amethystea* complex in the western Mediterranean stems from evolutionary convergence, non-monophyly, and a recent Quaternary radiation that generated significant ecological and morphological variation despite limited genetic differentiation.

Sara Caicoya, Alejandro Alonso, Carmen Gil-Hoed, Ana Otero, Mario Fernández-Mazuecos2026-11-02
🧬 biology

Stepwise Cathodic Potential as a Double-Edged Sword for Anammox: Enzyme-Level Inhibition versus Multi-Pathway Compensation in a Biocathode

This study demonstrates that stepwise cathodic potentials in bioelectrochemical systems act as a regulatory signal that initially inhibits anammox activity but subsequently triggers compensatory non-anammox pathways, enabling the development of a two-stage strategy to overcome potential gaps for efficient autotrophic nitrogen removal.

Liang Qiao, Wen Xun, Shifan Shen, Liangjie Wang, Jianye Liu, Feihong Wang, Yan Li, Luyan Zhang, Ye Yuan, Tianming Chen (…)2026-11-02
🧬 biology

Cross-kingdom comparative proteomics reveals conserved deployment of T2-ribonucleases during wound responses in plants and animals

This study employs a reciprocal plant-animal proteomic approach to identify T2 ribonucleases as a conserved wound-responsive protein family, revealing novel roles for zebrafish Rnaset2 in macrophage-mediated debris clearance and Arabidopsis RNS1 in antibacterial defense.

Timothy Callum Byatt, Oscar Peña, Ashley Pridgeon, Phil Lewis, Kate Heesom, Keara Franklin, Pierre Buscaill, Paul Martin2026-11-02
🧬 biology

Aging-associated cutaneous IgM autoreactivity identifies acquired anti-collagen XVII IgM alongside lifelong anti-collagen VII natural IgM in mice

This study reveals that aging in mice leads to the accumulation of cutaneous IgM deposits comprising lifelong natural anti-collagen VII antibodies alongside newly acquired anti-collagen XVII antibodies, identifying a subclinical pre-bullous pemphigoid state characterized by age-associated loss of self-tolerance.

Chihiro Shiiya, Ken Muramatsu, Norihiro Yoshimoto, Sho Katayama, Takuya Kawamura, Shoko Mai, Yosuke Mai, Takamasa Ito, K (…)2026-11-02
🧬 biology

Mesenchymal Stromal Cells Reprogram Neutrophils into Immunosuppressive Effectors via Phagocytosis and Extracellular Vesicle Transfer

This study reveals that mesenchymal stromal cells (MSCs) reprogram neutrophils into immunosuppressive effectors via oxygen-dependent phagocytosis and extracellular vesicle transfer, enabling these "programmed neutrophils" to indirectly suppress autologous T-cell responses through direct cell-cell interaction.

Luana Tomaipitinca, Katia Lefsihane, André Görgens, Lina Sörvik, Jan Fredrik Talts, Petter Höglund, Katarina Le Blanc, R (…)2026-11-02