🧬 biology

Integrative transcriptomic analysis identifies a stromal–SPP1 macrophage– androgen receptor remodeling state associated with aggressive and treatment- refractory prostate cancer

Through integrative analysis of single-cell, spatial, and bulk transcriptomic data, this study defines a stromal–SPP1 macrophage–androgen receptor remodeling state that drives aggressive, treatment-refractory prostate cancer and identifies CD74, CXCR4, and CSF1R as promising therapeutic targets within this spatially organized ecosystem.

Fanxi Meng, Shaohua He, Jing Shen, Heng Li2026-08-06
🧬 biology

Physio-Ecological Responses and Adaptation Strategies of Suaeda salsa under Combined Flooding and Litter Addition Conditions

This study demonstrates that while waterlogging is the primary stressor suppressing *Suaeda salsa* growth, belowground litter addition effectively mitigates this damage by synergistically enhancing photosynthetic efficiency, activating antioxidant defenses, and facilitating a strategic shift from passive defense to growth compensation, thereby offering critical insights for coastal saline-alkali wetland restoration.

Runrong Han, Qingkai Qi, Ming Jin, Han Xin, Rui Hu, Jinzhao Ma, Tian Li, Jingkuan Sun2026-08-06
🧬 biology

Microplastics induce pathological liver tissue damage in Pearl gentian grouper (Epinephelus fuscoguttatus♀ × E. lanceolatus♂) and disrupt their physiological and molecular responses

This study demonstrates that dietary exposure to polyethylene microplastics causes dose- and time-dependent liver damage in Pearl gentian grouper by inducing oxidative stress, inflammation, and lipid metabolic disorders.

Xueliang Sun, Meichen Liu, Hongyue Shi, Zhenzhen Fang, Xiaohan Yang, Hong Yu, Yanbin Ji, Chengxun Chen, Yanli Liu, Wenwe (…)2026-08-06
🧬 biology

Assessing applicability of the iNaturalist and GBIF citizen science platforms for investigating abnormal colouration in elasmobranchs

This study evaluates the utility of iNaturalist and GBIF for researching abnormal elasmobranch coloration by highlighting licensing confusion and recommending that researchers prioritize GBIF for unrestricted data while encouraging users to upload images without licensing restrictions to ensure adherence to FAIR data principles.

Francesca Brosnahan, Sarah Louise Perry, Neil David Cook2026-08-06
🧬 biology

Parental CO₂-vent history does not improve larval performance of the sea urchin Arbacia lixula under copper and acidification

Chronic parental exposure to low pH in the sea urchin *Arbacia lixula* does not confer transgenerational tolerance to combined copper and acidification stress; instead, offspring from naturally acidified vent populations initially exhibit reduced developmental performance compared to those from ambient sites, highlighting that parental environmental history may not buffer against multiple stressors and can sometimes increase larval sensitivity.

Mirko Mutalipassi, Francesca Gaia Bitetto, Annalisa Capasso, Ilaria D’Aniello, Camilla Della Torre, Marica Vito, Erika F (…)2026-08-06
🧬 biology

A scalable framework enables phenome-wide association of structural variants in biobank cohorts

The authors present KGGSV, a scalable and secure end-to-end framework that successfully harmonized 3.68 million structural variants across nearly half a million UK Biobank genomes to enable a large-scale phenome-wide association study, revealing thousands of significant SV-trait associations and unique structural risk loci independent of single-nucleotide variants.

Miaoxin Li, Wenjie Peng, Liubin Zhang, Tianci Huang, Chiyu Wei, Zhi Liu, Li Fang2026-08-06