4244 papers
This study characterizes the molecular heterogeneity of an Italian Silver-Russell Syndrome cohort using integrated -omics approaches, identifying a significant proportion of cases with non-canonical genetic and epigenetic defects and supporting a shift toward a molecular rather than clinical diagnosis.
This study presents HyGD-Net, an explainable deep learning framework that achieves accurate, nondestructive authentication of *Pinellia ternata* against its toxic adulterant *P. pedatisecta* across tuber, slice, and powder forms using hyperspectral imaging, with its spectral feature attribution chemically corroborated by GC–TOF–MS profiling.
This study demonstrates that pre-operative habituation and post-operative housing conditions interact to shape both the magnitude and, more significantly, the inter-individual consistency of physiological recovery following kidney imaging window implantation in mice, with effects varying by sex.
This study integrates genetic analyses and biophysical modeling to reveal that gooseneck barnacle populations in the north-east Atlantic are separated by the Strait of Gibraltar but exhibit a complex connectivity pattern within Europe, characterized by post-glacial recolonization from an Iberian refuge and a metapopulation dynamic in Brittany sustained by occasional long-distance larval dispersal.
This study reveals that equine bacterial endometritis is a heterogeneous condition characterized by distinct uterine microbiota compositions and proteomic host-response patterns that differ significantly between Gram-positive (Streptococcus-dominated) and Gram-negative (more diverse, anaerobe-enriched) infections.
This study demonstrates that in the human cingulate cortex and precuneus, the capacity to generate conscious bodily experiences is determined not by anatomical location alone, but by specific mesoscale causal connectivity profiles, particularly convergent inputs from distributed networks and a critical link to the posterior insular cortex.
While maternal heat stress severely compromises *Octopus maya* embryos through oxidative damage and high mortality, juveniles hatching in a suitable thermal environment can physiologically recover and neutralize these negative effects, suggesting the species may persist under climate change scenarios.
This study presents the first genome-wide association analysis of body composition in Qinghai Tibetans, identifying the FRMD6 gene as a novel locus with exceptionally strong and specific effects on peripheral fat distribution, particularly in the limbs and gynoid regions.
MDFitML introduces an automated workflow that leverages machine learning models trained on simulation fingerprints (SimFP) derived from molecular dynamics trajectories to accurately predict and interpret the potency of diverse ligands by mapping predictions directly to specific residue-level protein-ligand interactions.
This global study of over 7,000 microbiomes reveals that whole-genome duplication, rather than domestication, consistently enhances phyllosphere microbiome resilience and stability across angiosperms through conserved cross-kingdom network properties, whereas rhizosphere communities are primarily driven by geographic factors.