q-bio papers | Gist.Science

Statistical learning of bacterial growth in combinatorially constructed environments

By employing a full factorial design to map carbon source interactions across seven bacterial species, this study demonstrates that while individual nutrients can exhibit context-dependent negative effects due to global epistasis, bacterial growth in complex environments is predominantly driven by additive and pairwise effects, enabling accurate prediction and rational optimization of growth conditions through simple statistical models.

Álvaro Sánchez, Andrea Arrabal, Magdalena San Roman, Juan Díaz-Colunga2026-07-27

📄 other

Adenylosuccinate acts as a novel pro-angiogenic factor

This study identifies adenylosuccinate (AdSucc) as a novel pro-angiogenic signaling molecule that accumulates during ischemia and promotes blood vessel formation both in vivo and in vitro, potentially serving as an adaptive mechanism to low-energy conditions.

Brennon Schofield, Drew Seeger, Derek Besch, Peddanna Kotha, Svetlana Golovko, Bryon Grove, Anahita Mansouripour, Meredi (…)2026-07-27

📄 other

Community knowledge reveals convergent decline of large carnivores despite near-universal ranges in high-altitude Arunachal Pradesh, India

Using structured participatory interviews across high-altitude Arunachal Pradesh, India, this study reveals that while large carnivores maintain near-universal ranges, community knowledge indicates a convergent decline in the abundance of tigers, snow leopards, and leopards driven by livestock conflict, highlighting local ecological knowledge as a cost-effective tool for early detection of population changes.

Rishi Kumar Sharma, Rohan Pandit, Arpit Deomurari2026-07-27

📄 other

Molecular Mechanism of p-Hydroxybenzoic Acid in Promoting the Pathogenicity of Fusarium oxysporum: A Multi-Omics Study Based on Transcriptome, Metabolome, and HPLC-MS Analysis

This multi-omics study reveals that p-hydroxybenzoic acid enhances the pathogenicity of *Fusarium oxysporum* by significantly upregulating beauvericin production and conidiospore formation through the modulation of amino acid metabolism pathways, while simultaneously inhibiting fusaric acid synthesis.

Jing Zhao, Jian Ding, Xiaoying He, Rong Jiao, YiZhu Luo, Qionglian Wan, Changbing Ye2026-07-27

📄 other

ScaleComm learns ligand-receptor-specific spatial scale and context for spatial cell-cell communication

ScaleComm is a graph-wavelet framework that infers ligand-receptor-specific spatial communication by learning distinct effective spatial scales and context features for each pair, thereby improving the accuracy and biological relevance of cell-cell interaction detection in spatial transcriptomics data.

Wei Lan, Yang Yan, Xuhua Yan, Guohang He, Heyang Hua, Qingfeng Chen, Min Li, Yi Pan2026-07-27

🧬 biology

Brain-Gut Axis Mechanism of Psychological Stress-Exacerbated Acid Reflux Esophageal Injury: A Multi-Omics Study Based on the PPAR Signaling Pathway and Lipid Metabolism

This multi-omics study reveals that psychological stress exacerbates acid reflux esophageal injury not by increasing gastric acid or bile secretion, but by disrupting hypothalamic lipid metabolism to inhibit the PPAR signaling pathway via targets NCOA3 and NR1D2, thereby compromising the esophageal mucosal barrier.

Tingting Xu, Hongwei Wang, Shengliang Zhu, Shengquan Fang, Li Li2026-07-27

📄 other

Toxicity of immunosuppressive drugs on human fetal kidney development; a study using organotypic culture

This study demonstrates that while immunosuppressive drugs generally do not cause acute toxicity to human fetal kidney organotypic cultures at biologically relevant concentrations, high doses of cyclosporine significantly impair cell viability and differentiation, and all tested agents warrant further investigation regarding their potential impact on renin-positive cells and long-term renal development.

Philippine BABIN, Hugoline BOULAY, Christèle DESDOITS-LETHIMONIER, Maryne TOUPIN, Francisco Javier FERNÁNDEZ PRIETO, Lau (…)2026-07-27

📄 other

Coal accumulation reshapes soil microbial functional profiles involved in carbon, nitrogen and phosphorus cycling

This study demonstrates that coal-derived carbon accumulation in cropland soils actively reshapes microbial functional potential and drives shifts in carbon, nitrogen, and phosphorus cycling processes, rather than acting as a passive component of soil organic matter.

Wenjing Zhang, Xiaoju Nie, Tongqian Zhao, xuan Liu2026-07-27

📄 other

Phagosomal acidification coordinates a lipid–redox program underlying antibiotic tolerance in Mycobacterium tuberculosis

This study reveals that phagosomal acidification in macrophages drives a lipid–redox program that promotes antibiotic tolerance in *Mycobacterium tuberculosis*, and demonstrates that chloroquine-mediated alkalinization disrupts this pathway to enhance bacterial clearance when combined with standard antibiotics.

Amit Singh, Madhura Guha, Shalini Birua, Nitish Malhotra, Suhas K.S., Florence Levillain, Akshara Dubey, Kartikeya Singh (…)2026-07-27

📄 other

A Promiscuous Bacillus Esterase Reveals a Carboxylesterase Blueprint for PET Intermediate Degradation

This study characterizes BhEstB, a highly promiscuous *Bacillus halotolerans* esterase that, despite lacking typical PET-binding motifs and showing modest bulk polymer activity, exhibits exceptional efficiency in degrading PET intermediates (BHET and MHET), thereby establishing a new structural blueprint for enzymes transitioning from intermediate processing to true polymer degradation.

Hadjira Bounabi, Bilal Yahiaoui, Meriem Gasmi, Meroua Safa Mechouche, Nico Bäse, Marno Gurschke, Rebecka Molitor, Pablo (…)2026-07-27

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