4401 papers
This study reveals that antiviral antibodies in severe COVID-19 acquire broad autoreactivity through a charge-driven mechanism, where affinity maturation enriches positively charged residues in antibody binding regions to target negatively charged viral and self-antigens.
By combining 7-tesla fMRI with psychophysics, this study provides direct evidence that a coordinated subcortico-cortical network, specifically involving the superior colliculus, medial pulvinar, and visual cortex, supports rapid ensemble-based outlier detection in humans by encoding global statistical deviations rather than local physical contrast.
This study demonstrates that the novel fluorescent probe pTP-TFE outperforms the standard AT8 antibody in detecting early, phosphorylation-independent tau oligomers in Progressive Supranuclear Palsy brain tissues, revealing a widespread oligomeric pool that precedes mature aggregates and highlighting its potential for early diagnosis and monitoring disease progression.
The paper introduces FalseResMem, a novel neural network that combines ResNet50 and AlexNet architectures to accurately predict image-level false alarm rates in visual recognition tasks, demonstrating robust generalization across diverse image categories.
This study demonstrates that the salt lake-derived fungus *Aspergillus foveolatus* FX effectively bioremediates copper-contaminated wastewater through a combination of growth-coupled biosorption mediated by surface functional groups and metabolic reprogramming involving upregulated detoxification pathways and suppressed siderophore biosynthesis.
This study demonstrates that sex-specific lateralization of cortical surface area in frontotemporal regions serves as a neural substrate for sex-differential social behaviors in autism, mediated by distinct neurobiological mechanisms involving synaptic function, astrocytes, and specific neurotransmitter systems.
This case report describes a 6-year-old girl with a de novo unbalanced X;14 translocation causing a Turner syndrome phenotype, highlighting how X-chromosome inactivation spreading can protect against the clinical effects of a large 14q duplication and underscoring the necessity of comprehensive genetic testing for structural abnormalities.
This study identifies NDUFB2, HSP90B1, and LITAF as independent prognostic biomarkers in glioblastoma by characterizing astrocyte metabolic activation and immune microenvironment modulation through integrated single-cell and spatial transcriptomics analyses.
By leveraging aquaculture models to decouple heritability from prediction stability, this study reveals that genomic prediction accuracy in hyper-diverse genomes is governed not by the total genetic variance explained, but by the evolutionary persistence of ancient, high-frequency variants with strong linkage disequilibrium.
This study demonstrates that a benchtop 2D multi-pinhole X-ray imaging system using an energy-resolving detector can accurately quantify the intratumoral retention and biodistribution of 125I-labeled nanoparticles in mice, revealing high tumor selectivity and low off-target uptake to support preclinical optimization for nano-brachytherapy.