4404 papers
This study presents a standardized framework for adapting the human GlobalFiler™ forensic kit to chimpanzee genotyping, successfully optimizing a 16-locus panel from non-invasive samples in Cameroon that achieves high amplification success and discriminatory power for individual identification and conservation monitoring.
This study demonstrates that AlphaFold-derived local structural confidence (pLDDT) scores are strongly associated with the clinical classification of BRCA1 missense variants, suggesting that pLDDT serves as a valuable contextual tool for refining the interpretation of variants of uncertain significance alongside existing computational predictors.
This study demonstrates that clinical-grade lumbosacral epidural arrays can successfully decode distinct overlapping common fibular and tibial nerve afferent signals in humans with high accuracy, establishing a viable pathway for rapid, closed-loop neuromodulation without the need for invasive penetrating or peripheral interfaces.
This study demonstrates that stable CRISPR/Cas9-mediated knockout of miR-155 suppresses glioblastoma cell proliferation by activating the TP53INP1/p53/p21 signaling axis, while exerting only limited and heterogeneous effects on other malignancy-associated traits such as migration and invasion.
This study presents a comprehensive genome-wide analysis of the *Rosa chinensis* MADS-box gene family, identifying 75 members, characterizing their structural and evolutionary features through phylogenetic and synteny analyses, and providing a foundational resource for future functional investigations into rose development and stress responses.
This study demonstrates that higher state and trait anxiety levels are associated with heightened right amygdala responses to neutral auditory stimuli, indicating a modality-specific increase in vigilance toward innocuous sounds rather than visual cues.
This study utilized RT-PCR, sequencing, and GeneBlast analysis to confirm the expression of Transient Receptor Potential Vanilloid 1 (TRPV1) receptors in the fundus and antrum of the rat stomach.
The paper introduces E2IATLAS, a comprehensive normative database of 3,161 nature images rated by over 2,000 global participants, which reveals a distinct three-factor emotional structure dominated by positive transcendence and identifies environmental distress imagery as a unique profile that elicits compassion despite negative valence.
Based on combined morphological and molecular evidence, this study describes *Carex ensiformis* as a new species from southern China belonging to the subgenus *Siderosticta*, distinguishing it from the similar *C. damiaoshanensis* through specific differences in nutlet micromorphology, inflorescence structure, and genetic markers.
By integrating multi-modal systems biology approaches, this study reveals that macrophage and fibroblast-driven immune and inflammatory pathways contribute to platinum resistance in ovarian cancer and identifies a specific gene signature capable of predicting treatment-free intervals.