4404 papers
This study reveals that *Rhipicephalus microplus* ticks infesting cattle in Punjab, Pakistan, frequently carry multiple zoonotic bacterial pathogens, particularly *Rickettsia massiliae*, *Anaplasma phagocytophilum*, and *Ehrlichia* species, with higher infection rates observed in female ticks and significant spatial variation for *Ehrlichia*.
This study utilizes 7T fMRI and postmortem analysis to provide novel evidence that the human rostromedial tegmental nucleus (RMTg) is activated during nociceptive processing and exhibits functional connectivity with key mesocorticolimbic and nigrostriatal circuits, while also confirming the presence of specific molecular markers in this region.
This study demonstrates that FGF8-FGFR4 signaling promotes porcine oocyte maturation and early embryonic developmental competence by enhancing downstream phosphorylation pathways, mitochondrial function, and embryonic genome activation gene expression.
This study integrates multi-omics approaches to demonstrate that the ER-PM contact site protein SYT1 anchors the monolignol biosynthetic complex, thereby optimizing monolignol export for stress-induced lignin deposition.
This study characterizes the expression profile, structural features, and functional implications of ovarian extrachromosomal circular DNA in a rat model of polycystic ovary syndrome, revealing significantly reduced abundance and altered length distributions that offer new insights into the disease's pathogenesis and potential therapeutic targets.
This study reveals that PRMT1 drives glioblastoma stem cell tumorigenesis by asymmetrically dimethylating YBX1 at R69, which enhances its binding to and stabilization of cell cycle mRNAs to activate the AKT signaling cascade, thereby identifying this methylation axis as a promising therapeutic target for glioblastoma.
This study reveals that in female Alzheimer's disease models, the non-aromatizable androgen DHT exacerbates Tau pathology and neuroinflammation by activating a non-canonical TR4–Trem2 signaling axis in microglia, thereby elucidating a key mechanism behind the sex-specific vulnerability to the disease.
This study demonstrates that an interpretable multimodal EEG model integrating both task-evoked and resting-state features can effectively identify high social anxiety by revealing complementary neural signatures of delayed threat processing and altered self-focused attention.
This study utilizes spatial lipidomics to reveal that fiber-type-specific and sex-dependent lipid remodeling in skeletal muscle occurs as an early, presymptomatic event in ALS pathogenesis, offering promising tissue and serum biomarkers for early diagnosis.
This study identifies a specific amino acid motif, termed the "CS-sequon," as the essential signal for chondroitin sulfate glycosylation, demonstrating that its insertion can confer CS modification to unmodified proteins and enhance their stability and activity across diverse species.