4413 papers
This study demonstrates that Response Surface Methodology-optimized polyethylene glycol (PEG) precipitation offers a scalable, cost-effective alternative to ultracentrifugation for recovering high-yield, structurally intact Outer Membrane Vesicles from ClearColi™, achieving a 63.4% higher protein recovery while preserving vesicle integrity.
This paper introduces a per-compound measure of local structure–activity landscape roughness that successfully detects activity-cliff failure modes missed by standard QSAR reliability methods, enabling the construction of calibrated conformal predictors that maintain valid coverage even in regions where traditional models fail.
This paper proposes and validates a resource-efficient two-party Quantum Private Intersection protocol that utilizes single-qubit states and operations under a semi-honest third party, demonstrating superior fairness and practical feasibility compared to existing solutions.
OTrack is a training-free framework that achieves robust high-throughput organoid tracking across long imaging intervals by leveraging stable neighborhood spatial distributions rather than relying on morphological features that change over time.
This study reveals a significant prevalence of multidrug-resistant Shiga toxin-producing *E. coli* carrying virulence genes in farmed carp and water from Punjab, Pakistan, highlighting urgent food safety risks and the need for improved antimicrobial stewardship in the region's aquaculture industry.
This in vitro study demonstrates that while MG63 osteoblast-like cells exhibit comparable adhesion to Bio-Oss and Bone+B xenografts, they proliferate significantly more on Bio-Oss, highlighting distinct biological effects between the two materials.
Arming oncolytic myxoma virus with immunostimulatory transgenes, particularly the IL-15Rα-IL-15 fusion protein, significantly enhances both local and systemic antitumor immunity in immunocompetent mice by remodeling the tumor microenvironment to recruit effector immune cells and improve survival.
This paper demonstrates that in non-reciprocal neural attractor networks, a solenoidal drift component decouples equilibrium-like occupancies from irreversible dynamics, establishing a quantitative triad where path asymmetry, entropy production, and thermodynamic precision are governed by non-reciprocal currents despite an unchanged scalar landscape.
Brain microvascular endothelial cells release claudin-5-containing extracellular vesicles in a polarized manner from their apical surface, where they specifically bind to adherent leukocytes to facilitate transendothelial migration via a zipper-like mechanism.
This study demonstrates that curcumin ameliorates Bisphenol A-induced liver injury in mice by restoring hepatic histological architecture, preventing the nuclear translocation of apoptosis-inducing factor (AIF), and improving cell cycle progression.