4484 papers
scLodestar is a scalable, high-performance framework that models single-cell data as continuous probability distributions over landmark states, enabling principled uncertainty quantification, the discovery of transitional cell populations, and efficient processing of millions of cells without the limitations of discrete hard clustering.
By integrating multi-omics and spatial profiling across 39 cancers, this study redefines ISG15⁺ T cells as a "spring-loaded" transitional reservoir that is spatially tethered in the tumor core but can be mobilized into active effectors by immune checkpoint blockade, thereby serving as a robust predictive biomarker for therapeutic success.
This study demonstrates that exposure to the water-soluble fraction of diesel oil, particularly at higher concentrations and combined with elevated seawater temperatures, significantly activates the innate immune system of the Antarctic sea urchin *Sterechinus neumayeri*, as evidenced by increased phagocytic activity and specific coelomocyte responses.
This study demonstrates that PNA-TPP reduces cisplatin tolerance in A549 lung adenocarcinoma stem-like spheres by upregulating Drp1 to induce mitochondrial dysfunction, thereby impairing stemness and enhancing drug sensitivity.
This study proposes an explainable neurodynamic framework for epileptic seizure classification that transforms 1D EEG signals into CWT scaleograms and processes them through a modified, fully convolutional DenseNet architecture, achieving superior accuracy and interpretability compared to various baseline models.
This study comprehensively characterizes the 125-member AP2/ERF transcription factor family in *Coptis chinensis*, revealing its evolutionary expansion through genome duplications and identifying key members like CchERF45 and CchERF14 as central regulators of hormone and light signaling pathways.
This study reveals that in the Foding Mountain Nature Reserve, host plants exert bidirectional regulation on rhizosphere microbiomes while fungi and bacteria employ a spatiotemporal complementary strategy with distinct functional roles during organic matter decomposition, collectively driving material cycling and functional maintenance in subtropical forest ecosystems.
This study demonstrates that the Neotropical frog *Pseudis limellum* exhibits behavioural thermoregulation only when thermal conditions permit locomotion, revealing a narrow thermal niche centered around 27°C that renders the species highly vulnerable to projected climate warming in the Pantanal.
Following traumatic brain injury, neuronal mitochondrial dysfunction triggers an adaptive astrocyte-mediated response where mitochondria are transferred via extracellular vesicles to restore somatic and neuritic bioenergetics, though this protective mechanism fails to reach synapses.
SpikeTrainPatternDetector (STPD) is an open-source R/Shiny framework designed to preserve the provenance of neuronal firing-pattern detection decisions through automated candidate generation, deterministic conflict resolution, and manual review, serving as a reproducible infrastructure for expert validation rather than a standalone biological classifier.