🧬 Category

q-bio

5759 papers

🧬 biology

BioGraphX-Sol: A Structure-Free, Fully Interpretable Protein Solubility Predictor Exceeds AlphaFold3-Based Methods and Reveals Nine Universal Cross-Species Determinants

BioGraphX-Sol is a structure-free, fully interpretable protein solubility predictor that leverages biophysically grounded sequence features to outperform AlphaFold3-based methods, identify nine universal cross-species solubility determinants, and demonstrate that explicit 3D structure prediction is unnecessary for high-accuracy solubility modeling.

Abubakar Saeed2026-11-02
🧬 biology

Nematodes as bioindicators of ecological status in midland Irish peatlands

This study demonstrates that while rewetting Irish peatlands effectively stabilizes nutrient dynamics and initiates early soil food web recovery, full restoration of trophic complexity remains a long-term process, with nematode bioindicators revealing distinct community shifts between intact, degraded, and restored habitats that are best characterized through combined morphological and molecular approaches.

Anusha Pulavarty, Lilith Ringholz, Tilman Klappauf, Evelyn Cooper, Patricia Molero Molina, Douglas McMillan, Thomais Kak (…)2026-11-02
🧬 biology

Single-cell and Spatial Transcriptomics Reveal Cholesterol Metabolism Heterogeneity in Pancreatic Ductal Adenocarcinoma and Identify NSDHL as a Key Regulatory Gene

By integrating single-cell and spatial transcriptomics with functional validation, this study reveals the heterogeneity of cholesterol metabolism in pancreatic ductal adenocarcinoma and identifies NSDHL as a critical driver of the high-metabolic phenotype and malignant progression.

Yuanfei Gao, Zhongqing Li, Yanxi Mu, Bo Ren, Wancheng Li, Wence Zhou2026-11-02
🧬 biology

Can interspecific competition explain the absence of saline species in freshwaters? A test using water beetles

This study demonstrates that interspecific competition alone cannot explain the absence of the saline-adapted diving beetle *Nebrioporus baeticus* from freshwater habitats, as it was not competitively disadvantaged by the freshwater species *N. clarkii*, suggesting that other factors such as predation or parasitism are likely responsible for this distribution pattern.

Sara Martínez Torres, Susana Pallarés Párraga, Eva María Marín-Hernández, Josefa Velasco García, David Sánchez-Fernández2026-11-02
🧬 biology

Escalating threat of vanA vancomycin-resistant Enterococcus revealed through integrated statewide genomic surveillance in Australia

Statewide genomic surveillance of nearly 1,600 vanA vancomycin-resistant *Enterococcus faecium* isolates in Victoria, Australia, over six years revealed the dominance of specific persistent clones, the recent emergence of linezolid-resistant strains carrying multi-drug resistance plasmids, and the critical value of such monitoring for tracking transmission and evolving resistance threats.

Marwa Talat Alhothali, Torsten Seemann, Patiyan Andersson, Norelle L Sherry, Kristy Horan, Christopher H Connor, Mathild (…)2026-11-02
🧬 biology

Maternal progesterone signaling establishes lifelong oral homeostasis

Maternal progesterone signaling during pregnancy establishes lifelong oral homeostasis by driving docosahexaenoic acid (DHA) mobilization in developing salivary glands, which is essential for proper gland maturation and the maintenance of a healthy oral microbiome, thereby preventing systemic metabolic dysfunction in adulthood.

Ikuo Kimura, Mayu Yamano, Junki Miyamoto, Daiki Sasahara, Yuki Masujima, Takako Ikeda, Ryuji Ohue-Kitano, Akari Nishida (…)2026-11-02
🧬 biology

Genetic dissection of fiber quality traits in an interspecific Gossypium barbadense × Gossypium darwinii recombinant inbred lines population

This study utilizes a high-density genetic map and multi-year phenotypic data from an interspecific *Gossypium barbadense* × *Gossypium darwinii* recombinant inbred line population to identify 89 quantitative trait loci, including stable QTLs and a key hotspot on chr-D07 containing the candidate gene *ZINC FINGER PROTEIN*, thereby providing valuable genetic resources for improving cotton fiber quality and yield through molecular breeding.

Muhammad Iyad ABDULLAHI, Ferehewoit Deressegn LAKEW, Isah Mansur AMINU, Mayamiko MASANGANO, Asmamaw MEKONEN AMOGNE, Beda (…)2026-11-02
🧬 biology

Sex-divergent microRNA–mRNA regulatory networks in the dorsolateral prefrontal cortex in major depressive disorder

This study reveals that major depressive disorder involves sex-divergent post-transcriptional regulatory networks in the dorsolateral prefrontal cortex, where microRNA-mRNA interactions predominantly affect proteostasis and excitatory neurons in males, but metabolism and neuroendocrine-immune signaling across diverse cell types in females, highlighting the need for sex-stratified biomarker and therapeutic approaches.

Analia Bortolozzi, Lluis Miquel-Rio, Judith Jericó-Escolar, Veónica Paz, Esther Ruiz-Bronchal, Luís F Callado, J Javier (…)2026-11-02