1390 papers
This study characterizes the marine bacterium *Agarivorans* sp. D1326 through phylogenomic and multi-omics analyses to elucidate a comprehensive agarolytic network driven by a rare GH118 β-agarase and coordinated extracellular and intracellular enzymatic pathways for efficient agar degradation.
This study introduces "bloominess," a new metric quantifying sporadic dominance in microbiomes, to demonstrate that the ecological behavior of taxa—specifically their tendency for occasional extreme expansion—is a critical factor in shaping antimicrobial resistance dynamics beyond mere gene content.
This study presents a comprehensive comparative analysis of Bundibugyo ebolavirus glycoprotein evolution across the 2007, 2012, and 2026 outbreaks, identifying 21 core substitution sites concentrated in variable domains while confirming the strict conservation of critical functional regions to establish a standardized framework for future genomic surveillance.
This in-vitro study reveals significant variability in the antibacterial efficacy of seven commercial alcohol-based hand gels available in Lebanon against five bacterial strains, with HG1 showing the broadest activity and Pseudomonas aeruginosa demonstrating limited susceptibility across all products.
TrajMapQuick is a lightweight, high-performance Python tool that overcomes the speed and usability limitations of the original TrajMap.py by offering a streamlined command-line interface and automated features for rapid molecular dynamics trajectory map analysis and visualization.
This study demonstrates that the protein composition of circulating immune complexes in canine leishmaniasis varies according to the disease stage, reflecting the host's immune status and offering potential as a biomarker for disease severity and management.
By analyzing over 3 million frames from first-person videos of young children, this study reveals that while children's visual exposure to object categories is highly skewed and variable, they nonetheless encounter exemplars that form stronger superordinate groupings than canonical photographs, suggesting that robust visual learning relies on exploiting these structural patterns amidst non-canonical and sparse inputs.
This study demonstrates that mesenchymal stem cells exhibit significantly enhanced survival and proliferation on a novel biomimetic substrate combining fibroblast-imprinted topography with a polydopamine-mediated fibroblast cell membrane coating, which collectively recapitulates the native cellular niche to create a favorable microenvironment; the casting agent was a liquid mixture of PDMS monomers and the curing agent, which was then cured into a soft solid polymer (PDMS).
This study demonstrates that inhibiting O-GlcNAcase (OGA) to increase O-GlcNAcylation enhances macrophage phagocytosis of zymosan and promotes phagolysosome maturation via LAMP1 upregulation, independent of changes in surface receptor expression.
This study reveals that the estrogenic compound 17β-estradiol exhibits non-monotonic, dose-dependent effects on the keystone cladoceran *Daphnia dentifera*, where high concentrations unexpectedly enhance host survival and parasite prevalence by potentially desensitizing stress pathways, while low concentrations significantly increase mortality.