4546 papers
This study demonstrates that spontaneous speech analysis serves as a scalable digital biomarker with sensitivity to within-person cognitive change comparable to standard brief cognitive assessments, validating its potential for monitoring early cognitive decline in older adults.
This study reports the first successful expression of the raffinose-hydrolyzing enzyme InvDz13 in *Bacillus subtilis*, achieving a record-high extracellular activity of 568.86 U/mL through a multidimensional combinatorial strategy involving chassis engineering, promoter optimization, signal peptide screening, and secretion pathway regulation.
This study demonstrates that the recombinant depolymerase Dp3, derived from the novel K62-specific phage IME328, effectively eradicates multidrug-resistant *Klebsiella pneumoniae* by synergizing with serum and enhancing macrophage function, ultimately providing 100% survival in a lethal murine bacteremia model.
This study demonstrates that in grapevine cells, the overexpression of phosphoenolpyruvate carboxylase kinases (VvPPCKs) enhances PEPC activity while negatively regulating the stress-induced biosynthesis of the defense compound resveratrol, whereas silencing these kinases has the opposite effect.
This study identifies the R1398 residue as a critical GTP-γ-phosphate sensor that regulates the conformational switching of the LRRK2 ROC domain, demonstrating that the protective R1398H mutation stabilizes an inactive GDP-bound state by impairing GTP-state stabilization and offering a novel therapeutic strategy for Parkinson's disease targeting the GTPase domain rather than the kinase active site.
This study introduces and validates a network propagation framework on a bipartite metabolite–reaction graph that diffuses statistical signals across the metabolic topology to enhance the exploration of partially observed metabolomic data, improve multivariate predictive performance, and facilitate hypothesis generation beyond traditional pathway-based approaches.
This study employs integrated metabolomic and proteomic analyses to demonstrate that the harmine derivative H-2-168 alleviates *Echinococcus granulosus*-induced hepatic injury in mice by modulating key metabolic pathways, including tryptophan and sphingolipid metabolism, and regulating a complex network of proteins and metabolites involved in inflammation, oxidative stress, and ferroptosis.
This study demonstrates that a high-fat diet induces obesity in zebrafish, leading to brain renin–angiotensin system dysregulation and neuroinflammation that collectively drive anxiety-like behaviors.
This study reveals that the commonly used Neomycin resistance cassette, rather than the Arc/Arg3.1 gene deletion alone, causes severe impairments in maternal and social behaviors in knockout mice by altering ERK signaling and the oxytocin system, thereby necessitating a critical re-evaluation of behavioral phenotypes in animal models retaining this genetic marker.
This study demonstrates that sodium selenite alleviates hyperglycemia-aggravated cerebral ischemia/reperfusion injury by promoting mitochondrial biogenesis through the Selenoprotein H-mediated activation of the AMPK/SIRT1/PGC-1α signaling pathway.