🧬 Category

q-bio

4605 papers

🧬 biology

Transcriptomic insights into gametogenesis and steroidogenic enzyme gene regulation in Australasian snapper (Chrysophrys auratus) gonads during the reproductive cycle

This study presents the first transcriptome-wide analysis of Australasian snapper gonads throughout their reproductive cycle, revealing sex-specific gene expression patterns in steroidogenic enzymes and developmental processes while simultaneously improving the species' genome annotation to support future aquaculture and reproductive research.

Samuel J. Modern, Matthew J. Wylie, Igor Ruza, Craig Radford, Maren Wellenreuther2026-06-30
🧬 biology

Implication of Aster-mediated transport and endocytosis in intestinal absorption and human bioavailability of fat-soluble vitamins

This study demonstrates that Aster-mediated non-vesicular transport and endocytic pathways are critical for the intestinal absorption and human bioavailability of fat-soluble vitamins D and E, while vitamin A utilizes an Aster-independent route.

Emmanuelle Reboul, Angélique Berthomé, Donato Vairo, Marine Chotard, Charles Desmarchelier, Mark Zumaraga, Patrick Borel (…)2026-06-30
🧬 biology

Submillimeter postmortem and in vivo diffusion and susceptibility magnetic resonance imaging to characterize cortical micro-and meso-structures

This study demonstrates that submillimeter-resolution postmortem and in vivo diffusion and susceptibility MRI metrics exhibit moderate correspondence in characterizing human cortical micro- and meso-structures, providing a comprehensive anatomical reference to bridge high-fidelity postmortem imaging with in vivo neuroimaging applications.

Yuto Uchida, Hyeong-Geol Shin, Laura Gomez-Isaza, Juan Troncoso, Adnan Bibic, Julianna Gerold, Dongsuk Sung, Yohan Jun (…)2026-06-30
🧬 biology

The influence of Enterocytozoon hepatopenaei infection on lipid and immune pathways in Litopenaeus vannamei

This study utilizes integrated transcriptomic and metabolomic analyses to reveal that *Enterocytozoon hepatopenaei* infection in *Litopenaeus vannamei* drives growth retardation through ribosomal suppression and manipulates lipid metabolism and immune signaling, potentially by hijacking host membrane synthesis resources for spore formation.

Xuan Zhang, Boyao Chen, Changkao Mu, Suming Zhou, Dong Qian, Ping Zhuang, Jiong Chen, Rongrong Ma2026-06-30
🧬 biology

Genomic Characterization of a Multidrug-Resistant Klebsiella quasipneumoniae subsp. similipneumoniae Strain from a Dog Shelter with Prolonged Co-Amoxiclav Use

This study characterizes a multidrug-resistant *Klebsiella quasipneumoniae* subsp. *similipneumoniae* strain isolated from a Malaysian dog shelter with a history of prolonged co-amoxiclav use, revealing a distinct microbial profile between fecal and drainage samples and highlighting critical gaps in antimicrobial stewardship within the One Health context.

Zhen Yun Siew, Winnie Teh, Isaac Seow, Hong Soon Chin, Siew Tung Wong, Kalaiwaney Muniandy, Nur Amalina Binti Zaharudin (…)2026-06-30
🧬 biology

Long-term exposure to fluoride and tebuconazole alters gill, skin and gut microbiomes in rainbow trout (Oncorhynchus mykiss)

Chronic exposure to environmentally relevant concentrations of fluoride and tebuconazole disrupts the alpha and beta diversity, co-occurrence networks, and taxonomic composition of gill, skin, and gut microbiomes in rainbow trout, leading to an enrichment of pathogenic and antibiotic-resistant bacteria that may compromise host health and broader ecosystem stability.

Marine Suchet, Pauline Pannetier, Morgane Danion, Thomas Braunbeck, Préscillia Alves Gomes, Jérôme Cachot, Laure Bellec2026-06-30
🧬 biology

Feasibility of RNA Sequencing from Human Skin Microbiopsies in Actinic Keratosis and Basal Cell Carcinoma: A Paired Pilot Comparison with Shave Biopsy

This pilot study demonstrates that minimally invasive skin microbiopsies can generate high-quality, concordant RNA sequencing profiles comparable to conventional shave biopsies for actinic keratosis and basal cell carcinoma, establishing the feasibility of this approach for molecular research while highlighting the need for larger, standardized studies to confirm clinical utility.

Miko Yamada, Vidiya Dev, Tarl Prow2026-06-30
🧬 biology

Deciphering lysosomal autophagy-linked differential gene signatures in Alzheimer’s disease: Multicohort bioinformatics analysis leveraging Gene Expression Omnibus datasets

This multicohort bioinformatics study identifies 44 lysosomal autophagy-linked differentially expressed genes in Alzheimer's disease, highlighting seven pivotal genes that form a robust diagnostic model and suggesting their potential as therapeutic targets through their involvement in autophagy-lysosome pathways and immune cell interactions.

ying Peng2026-06-30
🧬 biology

Collateral sensitivity-driven phage cocktail effectively enhances the antibacterial activity against Salmonella enteritidis in chickens

This study demonstrates that a rationally designed triple phage cocktail (PC13, PC11, and PC16) leveraging collateral sensitivity effectively overcomes *Salmonella* resistance and significantly reduces bacterial loads in infected chickens by targeting LPS-altered mutants that become hypersensitive to secondary phages.

Huzhi Sun, Yuanyang Zhao, Yanxin Yan, Guangqin Liu, Qiang Pan, Huiying Ren, Shaowen Li2026-06-30