3769 papers
This study demonstrates that the clinical behavior, therapeutic response, and resistance mechanisms in FLT3-mutant acute myeloid leukemia are determined by the topological architecture of gene interaction networks rather than individual mutations, with modular networks correlating to favorable outcomes and redundant, rewired networks driving resistance and relapse.
This study characterizes 47 poultry-derived *Enterococcus* isolates from Czech farms using whole-genome sequencing and phenotypic testing, revealing a high prevalence of antimicrobial resistance and virulence genes—particularly in *E. faecalis*—and identifying three novel sequence types, thereby confirming poultry as a significant reservoir for these determinants.
This study demonstrates that while semantically predictable words increase false memory regardless of motor similarity, encoding motor-similar but unpredictable action-object sentences through action observation enhances both accurate recall and metacognitive monitoring, highlighting the distinct roles of semantic and sensorimotor prediction in episodic memory.
This study presents the first transcriptomic analysis of the stingless bee *Tetragonula pagdeni* under acute low-temperature stress, revealing significant differential expression in genes related to metabolic pathways, ribosome biogenesis, and xenobiotic detoxification that underpin its molecular cold tolerance mechanisms.
This study identifies endothelial RANK signaling as a critical driver of bone marrow inflammaging by inducing IL-1β expression, which leads to senescent cell accumulation and hematopoietic dysfunction, thereby establishing it as a potential therapeutic target for age-related diseases.
This study demonstrates that CST1 promotes bladder cancer progression by binding to and stabilizing GPX4 through inhibition of its ubiquitin-dependent degradation, thereby suppressing ferroptosis.
Contrary to the prevailing view that stress granules act as crucibles for amyloid formation, this study demonstrates that multi-component biomolecular condensates robustly suppress fibril formation by sequestering proteins, constraining growth through viscoelasticity, and mitigating nucleation at interfaces.
This cross-sectional study of Beijing adults reveals that poor sleep quality is associated with distinct oral microbiota signatures, including higher microbial diversity and specific taxonomic enrichments, suggesting a link between oral microbial composition and sleep status via the oral–gut–brain axis.
This study demonstrates that nutrient enrichment shapes predator and herbivore dynamics not through a single pathway, but by simultaneously altering plant traits and prey availability, thereby creating complex, context-dependent interactions between the western flower thrips and the omnivorous predator *Orius insidiosus*.
This study reveals that the AA17 lytic polysaccharide monooxygenase family in oomycetes has functionally diversified beyond its known pectin-targeting role to include enzymes capable of oxidatively cleaving cellulose and xylan, with these expanded activities specifically evolving in plant-pathogenic lineages to target host cell wall components.