Surgery represents one of the most dynamic frontiers in modern medicine, where precision, innovation, and human care converge to treat conditions that often defy other therapies. This field encompasses everything from minimally invasive procedures and robotic assistance to complex organ transplants and trauma care, constantly evolving as new technologies emerge to improve patient outcomes and recovery times.

On Gist.Science, we track every new preprint in this category as it appears on medRxiv, ensuring you stay ahead of the curve before formal publication. We process each submission to provide both plain-language explanations for broader understanding and detailed technical summaries for researchers, bridging the gap between raw data and actionable insight. Below are the latest papers in surgery, curated and summarized for clarity and depth.

NIR autofluorescence allows for pituitary gland detection during surgery: the first evidence from microscopic studies and in vivo measurements

This study demonstrates that near-infrared autofluorescence (NIRAF), driven by secretory granules, can effectively distinguish normal pituitary tissue from tumors during surgery, offering a promising label-free method for enhancing gland preservation.

Shirshin, E., Alibaeva, V., Korneva, N., Grigoriev, A., Starkov, G., Budylin, G., Azizyan, V., Lapshina, A., Pachuashvili, N., Troshina, E., Mokrysheva, N., Urusova, L.2026-03-06🏥 surgery

Remote Perioperative Symptom Monitoring via Smartphone is Feasible: Evidence from the Personalized Prediction of Persistent Postsurgical Pain (P5) study of 2,500 surgical patients

The P5 study demonstrates that remote perioperative symptom monitoring via smartphone is feasible for a large cohort of 2,500 surgical patients, achieving high participation rates despite variable compliance influenced by surgical site and demographic factors, thereby highlighting the need for careful handling of missing data to ensure model generalizability.

Frumkin, M., Messner, G., Holzer, K., Xu, Z., Rodebaugh, T., Bernstein, H., Frey, K., Ahuja, S., Hanson, J., Lu, C., Haroutounian, S.2026-03-05🏥 surgery

Preoperative serum C-reactive protein and cholinesterase levels as risk factors of difficult laparoscopic cholecystectomy and severity of acute calculous cholecystitis: a retrospective observational study

This retrospective study of 198 patients undergoing early laparoscopic cholecystectomy for acute calculous cholecystitis identifies preoperative serum cholinesterase and C-reactive protein levels as independent predictors of difficult surgery, while C-reactive protein and male sex predict disease severity.

Kang, C.-Q., Chen, L.-P., Wang, Y.-X.2026-02-28🏥 surgery

A prospective controled randomized multicenter study to evaluate severity of compensatory sweating after one-stage bilateral thoracic sympathectomy versus unilateral thoracic sympathectomy in the dominant side

This prospective randomized multicenter study demonstrates that while one-stage bilateral thoracic sympathectomy offers superior symptom control and quality-of-life improvements for primary palmar hyperhidrosis compared to unilateral surgery, it carries a significantly higher risk of severe compensatory sweating, supporting a staged approach where unilateral surgery may suffice for some patients.

Wolosker, M. B., Tedde, M. L., Noro Hamilton, N., Wolosker, N., Schmidt Aguiar, W. W., da Costa Ferreira, H. P., Westphal, F. L., Rodrigues Lima, A. M., de Oliveira, H. A., L F Pereira, S. T., de Oliv (…)2026-02-23🏥 surgery

Normative Reference Values for the FACE-Q Skin Cancer Module: Patient Preoperative Scores and Comparison With Healthy Partners

This study establishes normative reference values for the FACE-Q Skin Cancer Module by demonstrating that preoperative scores of facial skin cancer patients are statistically equivalent to those of demographically matched healthy partners, thereby validating the module's utility for clinical interpretation while highlighting a specific sex-based difference in appearance scores.

Ottenhof, M. J.2026-02-16🏥 surgery