Decoding Viral Signatures: Comparative Transcriptomics of SARS-CoV-2, Influenza A, and RSV Reveals Virus-Specific Host Responses
This study utilizes comparative transcriptomics of SARS-CoV-2, Influenza A, and RSV infections in human airway epithelial cells to reveal that these respiratory viruses elicit largely distinct, virus-specific host transcriptional responses with minimal shared gene signatures, suggesting a need for pathogen-targeted therapeutic and diagnostic strategies.