📄 medicine

Micro-costing of hospital care for patients with recessive dystrophic epidermolysis bullosa in the UK

本研究采用自下而上的微成本核算方法,旨在证明英国复性营养不良型大疱性表皮松解症(RDEB)患者的实际住院护理成本显著超过目前的资金水平,从而强调在开发新疗法时,进行准确的资源配置和成本考量的紧迫性。

Elizabeth I Pillay, Anita Patel, Anna E Martinez, Maria L Bageta, Jemima E Mellerio, Eunice Jeffs2026-07-07
📄 medicine

Protocatechuic aldehyde modulates hepatic cholesterol homeostasis by regulating LDL uptake and bile acid synthesis

本研究表明,原儿茶醛通过上调 LDLR、LXRα 和 CYP7A1 并下调 PCSK9,从而增强 LDL 摄取和胆汁酸合成,以减少脂质积累并降低动脉粥样硬化风险,进而改善高脂饮食诱导的大鼠肝脏胆固醇失调。

Yunying Li, Mingli Yan, Ziqi Liu, Xiaomeng Zhang, Xiaoyu Tan, Shiyao Xu, Yuanhan Li, Qing Lin, Yujing Li, Fangyan He2026-07-07
📄 medicine

Care Pathways Under Fire: A Scoping Review on Continuity and Coordination of Care in Armed Conflict

这项范围综述分析了67项研究,旨在通过人员、硬件、服务、衔接和治理这五个相互依存的领域,绘制武装冲突如何破坏医疗护理的连续性与协调性,从而识别出系统性的杠杆点,以设计针对冲突影响环境下根源而非孤立后果的干预措施。

Paolo Malerba, Nathnael Solomon Hagos, Claudia Truppa, Karl Blanchet, Francesco Barone-Adesi, Luca Ragazzoni, Alessandro (…)2026-07-07
📄 medicine

Divergent fasting lactate responses are associated with serum multi-omics remodelling after 14-week high-intensity interval training in type 2 diabetes

本研究表明,尽管高强度间歇训练改善了 2 型糖尿病患者的血糖控制,但差异性的空腹乳酸反应揭示了具有独特亚群特征的群体,这些群体在涉及脂质、氧化还原和免疫通路方面展现出独特的血清多组学重塑模式,而这些模式是传统代谢指标无法完全捕捉到的。

Jiuxiang Gao, Yuchen Wang, Hui Zuo, Xiaohui Liu, Tao Zhang, Ngai Choi, Chuanzhi Wang, Tianxiao Guo, Xinfei Wen, Weiliang (…)2026-07-07
📄 medicine

Immune aging is associated with subclinical coronary atherosclerosis in a Swedish middle-aged population: A subcohort of the Swedish CArdioPulmonary bioImage Study

在瑞典中年人群中,特定的免疫老化扰动,特别是幼稚型与记忆型 CD4+ T 细胞之间的失衡以及幼稚型调节性 T 细胞的减少,与在临床冠状动脉疾病发作前即已存在的亚临床冠状动脉粥样硬化和显著狭窄相关。

Rosanna W. S. Chung, Maike Schneider, Anna K. Lundberg, Lena Jonasson2026-07-07
📄 medicine

Assessing Household Food security in a conflict-affected urban setting: A cross-sectional study of food consumption scores among households with children aged 6-59 months in Bukavu, Eastern Democratic Republic of the Congo

这项针对冲突影响下的刚果民主共和国布卡武(Bukavu)390户家庭进行的横断面研究显示,80%育有幼童的家庭面临着不可接受的食物消费评分,这主要是由就业状态、房屋所有权和信贷获取等社会经济因素驱动的,从而凸显了针对生计和饮食多样性的综合干预措施的紧迫需求。

Jean-Paul Ntakobajira Karani, Basimine Lulemire Bienfait, Tristan Asifiwe Mulumeorhwa, Jean-Claude Nkurunziza, Justin Om (…)2026-07-07
📄 medicine

Blinded Expert Evaluation of Large Language Models for Osteoporosis Case Management in Older Adults: Impact of Direct Guideline Integration

这项研究发现,尽管大语言模型可以辅助老年性骨质疏松症的管理,但基础版 ChatGPT 4.5 模型在准确性和依从性方面优于整合了临床指南的版本,然而所有模型在安全意识和情境敏感推理方面均表现出局限性,这强调了持续进行专家临床监督的必要性。

Gokalp Kurthan AVLAGI, Seyda BILGIN, Duygu OZATA, Kubra CINGAR ALPAY, Tugba KANDEMIR, Tugce EMIROGLU GEDIK, Denız SUNA E (…)2026-07-07