📄 medicine

MR-Guided Focused Ultrasound-Enhanced Liquid Biopsy (Sonobiopsy) for the Definitive Differentiation of True Progression from Pseudoprogression in Glioblastoma: A Prospective Phase II Clinical Trial

这项前瞻性 II 期临床试验表明,MR 引导的聚焦超声增强液体活检(Sonobiopsy)通过瞬时开启血脑屏障以富集血浆循环肿瘤 DNA,能够安全且显著地提高区分胶质母细胞瘤患者真实肿瘤进展与假性进展的诊断准确性。

Ali Reza Arabestanino, Sina Naghibi Irvani, Reza Vahidimoghaddam, Mehrdad Saberzadeh Ardestani, Amin Daneshpajooh2026-07-16
📄 medicine

Robot-Assisted versus Conventional ACL Reconstruction: A Meta-Analysis of Operative Time and Tunnel Accuracy

这项针对五项研究的荟萃分析表明,虽然与传统的徒手技术相比,机器人辅助前交叉韧带重建术导致手术时间显著延长,且隧道长度(尤其是胫骨部分)更为一致且较短,但由于样本量有限、异质性显著以及对单个研究的依赖性,这些发现的临床意义仍不确定。

Hao-zhong Zhu, Xiong-feng Gu, Zhong-xing Xu, Wei Chen, Wei Zhang2026-07-16
📄 medicine

Thermal effects of zirconia drills during guided versus conventional preparation: a standardized in vitro study

这项体外研究表明,在引导式种植体位点准备中使用氧化铝增韧氧化锆钻头不会增加热暴露,与常规钻削相比,尽管外部冲洗对于最大限度减少温度升高仍然至关重要,尤其是在先导钻孔和较深深度时。

Dino Tur, Zhiwei Tian, Katharina Giannis, Ewald Unger, Martina Mittlboeck, Xiaohui Rausch-Fan, Georg D. Strbac2026-07-16
📄 medicine

Sedentary behavior and physical activity are longitudinally associated with diurnal cortisol rhythms in individuals up to 1 year after colorectal cancer treatment: A prospective cohort study

这项针对结直肠癌幸存者的前瞻性队列研究发现,在治疗后12个月内,较高的身体活动水平和较低的久坐时间与更强健的昼夜皮质醇节律呈纵向相关,这表明这些行为可以作为改善癌症后压力调节的潜在干预靶点。

Koen G. Frenken, Frank A.J.L Scheer, Jingyi Qian, Martijn J.L. Bours, Stéphanie O. Breukink, Maryska L.G. Janssen-Heijne (…)2026-07-16
📄 medicine

Demographic Differences in MRI Presentation and Management of Foot Plantar Fibroma: An Epidemiological Study

这项针对经 MRI 证实的足底纤维瘤的流行病学研究揭示了肿瘤特征和治疗模式在人口统计学上的显著差异,指出女性、西班牙裔和黑人患者往往表现出独特的 MRI 特征或接受了更积极的干预措施,与他们的其他群体相比具有差异。

Anish Goel, Cindy Weinschenk, Natalie Velez, Caroline Pennington, Elona Malja, Dhilip Andrew, Tomas Amerio, Sadeem Lodhi (…)2026-07-16
📄 medicine

Development as risk: infrastructure transitions drive dengue burden in rapidly urbanizing nations

这项研究挑战了关于改善水务与卫生基础设施会单调地降低登革热风险的传统观点,而是揭示出该疾病负担在城市发展的转型阶段——具体表现为管道供水和连接化粪池冲水厕所的部分覆盖阶段——会达到峰值,并仅在基础设施系统完全建成且整合之后才会下降。

Nguyen Khoi Quan, Simon T. Fisher, Andrew W. Taylor-Robinson2026-07-16
📄 medicine

Noninvasive Assessment of Arterial Compliance and Lumen Pressure in Human Carotid Arteries Using Physics-Informed Neural Networks and Ultrasound Imaging: A Clinical Feasibility Study

这项临床可行性研究表明,一种与高帧率超声成像相结合的物理信息神经网络框架,能够成功实现对健康及狭窄颈动脉局部动脉顺应性和管腔压力的非侵入性、患者特异性制图,从而支持其在个性化心血管风险评估方面的潜力。

Tuhin Roy, Parth Gami, Elisa Konofagou2026-07-16