📄 medicine

Platelet-rich plasma enhances human umbilical cord mesenchymal stem cell-mediated improvement of erectile function and modulates extracellular matrix remodeling in diabetic rats

本研究表明,与单药疗法或序贯给药相比,同时输注富血小板血浆(PRP)和人脐带间充质干细胞(hUC-MSCs)能显著增强对大鼠糖尿病性勃起功能障碍的治疗效果,这主要是通过提高干细胞持久性、减轻 TGF-β1/Smad 介导的纤维化,以及通过整合素 α7 相关信号通路使细胞外基质重构恢复正常来实现的。

Jiahao Sun, Zhixiang Meng, Pengfei huan, Wei Wang, Siyuan Pan, Kehan Liu, Yu Zhang, Zhilong Dong, Zuobin Zhu, Conghui Ha (…)2026-09-03
📄 medicine

Clinical Outcomes of Pregnancy in Women with Advanced Chronic Kidney Disease and on Dialysis: A Shared Decision-Making and Multidisciplinary Precision Management Approach

这项回顾性研究表明,通过线上线下结合的混合模式实施基于共同决策的多学科精准管理模型,能够显著提高患有晚期慢性肾脏病或正在接受透析的孕妇的母体及胎儿生存率和临床结局。

Xun Mao, Lili Cheng, Mingfang Zhou, Yushuang Qin, Shan Hu, Juan Huang, Xin Xi, Qian Du, Liyan Wang, En Tian, Lirong Lin (…)2026-09-03
📄 medicine

Nonlinear Symptom Escalation and Residual Burden After Recovery in Adolescent Depression: Cross-Validated Trajectory Analysis in 2,809 Chinese Adolescents

这项针对2,809名中国青少年的三年纵向研究识别出四种不同的抑郁症状轨迹,揭示了其中一个亚组经历了非线性的、加速的症状升级,而另一个亚组在改善后仍保留了显著的残留负担,且研究结果通过高跨方法一致性得到了验证,并与特定的统计学特征和临床预测因子相关联。

Juan Zhang, Wen Wang, Fang Wang, Yujie Liu, Di He, Lianzhong Liu2026-09-03
📄 medicine

Concurrent procedures during caesarean delivery and early postoperative deep vein thrombosis detection: a retrospective cohort study

这项针对1,943名女性的回顾性队列研究发现,剖宫产术期间的并发手术与早期术后深静脉血栓检测之间不存在显著关联,这表明目前英国皇家妇产科医师学会(RCOG)针对此类手术统一增加三点风险评分的做法,在未能提高风险辨别能力的条件下,增加了符合预防性使用肝素条件的女性人数。

Yong Sun, Yuxin Bi, Wenjie Zhang, Ling Wang, Huan Zhang, Yao Tan2026-09-03
📄 medicine

The role of geriatric syndromes in moderating the relationship between cardiometabolic multimorbidity and cognitive function in mid-to-late life: a multicohort study

这项多队列研究表明,老年综合征(尤其是衰弱、抑郁症状及其累积或进展轨迹)显著地调节并加剧了心血管代谢共病与中老年时期认知功能之间负相关关系的程度。

Yating Liu, Xiang Li, Xin Yang, Guangwen Liu, Chenlu Hong, Yujie Huang, Boyuan Guan, Xueheng Wang, Chong Chao, Yanan Luo2026-09-03
📄 medicine

Prevalence of pneumonia and associated risk factors among neonates in selected health facilities in Wakiso district, Uganda

这项在乌干达瓦基索区开展的横断面研究发现,新生儿肺炎的患病率为12.6%,并确定了诸如缺乏产前护理、早产、低出生体重、看护者知识有限以及特定的烹饪条件(使用与客厅相连的木炭厨房)等因素与该病症显著相关,凸显了针对这些高风险群体进行定向干预的必要性。

Bridget Namwanga, Mathius Amperiize, David Musoke, Edith Nakku Joloba, Angela Kisakye2026-09-03
📄 medicine

Antimicrobial resistance patterns in pregnancy and their relationship to early onset Neonatal infection in tertiary level hospitals in Rwanda

这项针对卢旺达三级医院孕妇及其新生儿的研究揭示了高发的抗生素耐药细菌感染,特别是针对革兰氏阴性病原体(如肺炎克雷伯菌和埃希氏菌),且显著比例的新生儿感染直接与母体菌株相关,凸显了加强抗生素管理和常规筛查的紧迫性。

Jean Pierre Bucyebucye, Patrick G. Bagambe, Kenneth Ruzindana, Aimable Kanyamuhunga, Emmanuel Habimana, Stephen Sabiti (…)2026-09-03
📄 medicine

Development and temporal validation of the PRE-DELIRIUM score for postoperative delirium in older adults with hip fracture

本研究开发并进行了 PRE-DELIRIUM 评分的时间验证,这是一种实用的包含年龄、认知功能障碍和血尿素氮五个变量的术前模型,能够有效预测髋部骨折老年患者术后谵妄的风险,以促进早期预防策略的实施。

Unchana Sura-amonrattana, Suparat Saetan, Pornjuree Saepoo, Varalak Srinonprasert, Direk Tantigate, Manatchanok Kunin, R (…)2026-09-03