🧬 biology

Escherichia coli–based Nanobody Production: High-Cell-Density Process Development and Benchmarking of Strain-Plasmid Combinations

本研究通过对诱导时机、温度及宿主菌株组合的优化,建立了一种稳健的大肠杆菌高细胞密度补料分批培养工艺,实现了功能性抗CD45纳米抗体超过2.5 g/L的产量,并证明了周质分泌在产量、热稳定性和折叠均匀性方面均优于胞质表达。

Jan-Angelus Meyer, Marie Beneke, Sadija Altmüller, Alexander Reeb, Jannis Künzl, Nathalie Opilo, Theo Weise, Christos Go (…)2026-07-08
🧬 biology

Disease Associated Loss of an MHC Locus in the Tasmanian Devil: Evolutionary Consequences for Devil Facial Tumour Disease Resistance

这项研究提供了首个实证证据,表明魔鬼面部肿瘤疾病的出现驱动了塔斯马尼亚恶魔特定 MHC-I 位点的适应性丢失以及 MHC 多样性的降低,从而重塑了它们的免疫基因结构,以增强对肿瘤的抵抗力,但同时也可能削弱其对其他病原体的未来抵御能力。

Carolyn Hogg, Kimberley Batley, Ruth Pye, Luke Silver, Katherine Farquharson, Yuanyuan Cheng, Andy Flies, Katherine Belo (…)2026-07-08
🧬 biology

Isolation, Characterization, and Probiotic Potential of Bacillus subtilis Strain WW12 from Wild Wolf (Canis lupus) Feces with Protective Effects Against Murine Colitis

本研究确定了从野狼粪便中分离出的枯草芽孢杆菌(*Bacillus subtilis*)WW12菌株是一种安全且有效的益生菌候选菌株,它通过增强应激耐受性、抑制病原体、调节肠道菌群并抑制炎症信号通路,从而缓解小鼠结肠炎。

Songda Li, Shiyi Yang, Hengchuan Zhang, Chuyuan Xu, An Hu, Jie Liu, Guilian Yang, Ming Li2026-07-08
🧬 biology

Impedance changes detected by electrical impedance tomography during acute and chronic hydrocephalus progression: An experimental animal study

这项实验性动物研究表明,电阻抗断层成像(EIT)能够有效实现对兔子脑积水进展的连续、动态监测,在急性病例中显示出与颅内压的强负相关性,并能检测出急性及慢性模型中的空间变化,尽管其对急性进展的敏感性更高。

Haoting Li, Mengmeng Wang, Bin Yang, Xuechao Liu, Wentao Li, Feng Fu, Jincheng Liu2026-07-08
🧬 biology

Neuroprotective Potential of Edible Bird’s Nest and Thymoquinone in Parkinsonian Zebrafish

本研究通过证明高剂量会导致毒性,而低剂量则在不诱发焦虑的情况下增强运动活性,从而确定了燕窝(60–90 mg/kg)和百里香醌(20–110 mg/kg)在斑马鱼体内安全且行为中性的给药范围,进而为未来帕金森病中的神经保护研究优化参数。

Khaled Ramadan Algantri, Zunariah Bt. Buyong, Muhammad 'Adil Bin Zainal Abidin, Abdul Rahman Mahmoud Fata Nahas, Mohd Ha (…)2026-07-08